| 一种新的实验性急性肾功能衰竭动物模型的研究 |
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| 引用本文： | 吴广礼,田牛. 一种新的实验性急性肾功能衰竭动物模型的研究[J]. 实验动物与比较医学, 1991, 0(4) |
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| 作者姓名： | 吴广礼 田牛 |
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| 作者单位： | 北京军事医学科学院放射医学研究所，北京军事医学科学院放射医学研究所 现在白求恩国际和平医院内二科工作。 |
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| 摘 要： | 观察了大鼠左肾动脉注射油酸后肾微循环及实质细胞的改变。注射油酸后,肾内脉动血管弹性降低,紧张度增加,肾组织血液灌流量降低,肾小球及小管周围毛细血管内皮细胞肿胀、坏死,肾组织不需辅酶的脱氢酶减少,肾小管坏死,血清尿素氮升高。这些结果说明,大鼠左肾动脉注射油酸可引起急性肾功能衰竭(ARF),可用来模似人类的起源于肾微循境障碍的缺血性APF。
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| 关 键 词： | 微循环 急性肾功能衰竭 油酸 |
A NEW EXPERIMENTAL ACUTE RENAL FAILURE MODEL |
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| Guang--Li Wu,Niu. Tian Academy of millitary medical science,Institute of radiation medical science,Beijing. A NEW EXPERIMENTAL ACUTE RENAL FAILURE MODEL[J]. Laboratory Animal and Comparative Medicine, 1991, 0(4) |
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| Authors: | Guang--Li Wu Niu. Tian Academy of millitary medical science Institute of radiation medical science Beijing |
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| Affiliation: | Guang--Li Wu,Niu. Tian Academy of millitary medical science,Institute of radiation medical science,Beijing |
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| Abstract: | An experimental model of acute renal failure (ARF) has been deve-loped by injection of oleic acid to left renal artery of rat. The changes of microcircu-lation and parenchyma cells of rat kidney were observed at 10 minutes, 6 and 24hours after the injection. Following the injection, the elasticity of renal pulsing bloodvessels became weaker and tense was elevated, renal tissue blood flow remarkably dec-reased, the severe edema and necrosis of renal microvessel endothelium cells werefound, TTC staining occured intensive positive, tubular necrosis, BUN was significa-ntly elevated. These results demonstrated that an experimental model of ARF in ratcould be induced by injection of oleic acid to left renal artery. Tbis model was chara-cterized by the disturbance of kidney microcirculation. |
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| Keywords: | Acute renal failure microcirculation oleic acid |
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