|
|||||
|
|
A new polymorphism in the GRP78 is not associated with HBV invasion |
|
| Authors: | Xiao Zhu Yi Wang Tao Tao Dong-Pei Li Fei-Fei Lan Wei Zhu Dan Xie Hsiang-Fu Kung |
| Affiliation: | 1. Institute of Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, Guangdong Province, China;State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China 2. State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China 3. Department of Digestive Diseases, Zibo Central Hospital, Zibo 255000, Shandong Province, China 4. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China 5. Laboratory of Integrated Biosciences, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China |
| Abstract: | AIM: To examine the association between-86 bp (T > A) in the glucose-regulated protein 78 gene ( GRP78) and hepatitis B virus (HBV) invasion.METHODS: DNA was genotyped for the single-nucleotide polymorphism by polymerase chain reaction followed by sequencing in a sample of 382 unrelated HBV carriers and a total of 350 sex-and age-matched healthy controls. Serological markers for HBV infection were determined by enzyme-linked immunosorbent assay kits or clinical chemistry testing.RESULTS: The distributions of allelotype and genotype in cases were not signi.cantly different from those in controls. In addition, our .ndings suggested that neither alanine aminotransferase/hepatitis B e antigen nor HBV-DNA were associated with the allele/genotype variation in HBV infected individuals.CONCLUSION:-86 bp T > A polymorphism in GRP78 gene is not related to the clinical risk and acute exacerbation of HBV invasion. |
| Keywords: | Acute exacerbation Glucose-regulated protein 78 Hepatitis B virus Single-nucleotide polymorphism |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 | |