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Heparin-like effect of polymethacrylic acid on the reaction between thrombin and antithrombin-III |
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| Authors: | Raymund Machovich,Istv n Horv th |
| Affiliation: | a Postgraduate Medical School, First Department of Medicine, 1389, Budapest, Hungary b Second Institute of Biochemistry, Semmelweis University Medical School 1088, Budapest, Hungary |
| Abstract: | The effect of polymethacrylic acid on the reaction between thrombin and antithrombin-III was investigated. It was found that polymethacrylic acid accelerated the inactivation rate of thrombin by antithrombin-III, whereas this polyanion did not affect thrombin activity. It is suggested that polymethacrylic acid may simulate the action of heparin on thrombin and antithrombin-III. |
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