Investigation of the Mechanism of Clearance of AMG 386, a Selective Angiopoietin-1/2 Neutralizing Peptibody,in Splenectomized,Nephrectomized, and FcRn Knockout Rodent Models |
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| Authors: | Benjamin Wu Jessica Johnson Marcus Soto Manuel Ponce Dominador Calamba Yu-Nien Sun |
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| Institution: | (1) Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., One Amgen Center Drive, Mailstop 28-3-B, Thousand Oaks, California, USA; |
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| Abstract: | Purpose To investigate the mechanisms of clearance of AMG 386, an investigational recombinant peptide-Fc fusion protein (peptibody)
that blocks tumor angiogenesis by neutralizing the interaction between angiopoietin-1 and -2 and the Tie2 receptor. |
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