| DNA错配修复和临床肿瘤新进展 |
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| 引用本文： | 马守成,赵达.DNA错配修复和临床肿瘤新进展[J].基础医学与临床,2011,31(12):1402-1405. |
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| 作者姓名： | 马守成 赵达 |
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| 作者单位： | 兰州大学第一医院肿瘤内,甘肃兰州,730000 |
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| 摘 要： | DNA复制是一个严谨有序的过程,细胞分裂时,碱基错配的概率约为1/1010～1/109.错配修复系统(MMR)是一个从细菌到真核细胞皆保守的DNA修复途径,它负责修复DNA中错配的碱基,或者DNA聚合酶的校对功能失调而引起的复制错误,插入,遗失碱基,使DNA整体复制的保真度增加50～1000倍.MMR系统失控会导致DN...
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| 关 键 词： | DNA错配修复 微卫星不稳定性 结直肠肿瘤 乳腺肿瘤 前列腺肿瘤 神经胶质瘤 |
The news for MMR and clinical cancer |
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| MA Shou-cheng,ZHAO Da.The news for MMR and clinical cancer[J].Basic Medical Sciences and Clinics,2011,31(12):1402-1405. |
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| Authors: | MA Shou-cheng ZHAO Da |
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| Institution: | MA Shou-cheng,ZHAO Da(Dept.of Oncology the First Hospital of Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | DNA replication is an extraordinarily faithful process,mutation occures at a frequency of 1/109 or 1/1010 base pairs per cell division.The MMR pathway,a DNA repair pathway conserved from bacteria to humans,targets base substitution mismatches and insertion-deletion mismatches that arise as a result of replication errors that escape the proofreading function of DNA polymerases.In doing so,MMR contributes an additional 50~1000-fold to the overall fidelity of replication.Thus,inactivation of MMR confers a stro... |
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| Keywords: | DNA MMR MSI HNPCC(CRC) breast cancer prostate cancer Glioma |
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