| 附子汤与芍药甘草汤合用的镇痛作用及机制研究 |
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| 引用本文： | 李睿明,李卫平,雷朝霞,郝泽峰. 附子汤与芍药甘草汤合用的镇痛作用及机制研究[J]. 现代中西医结合杂志, 2002, 11(23): 2323-2325 |
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| 作者姓名： | 李睿明 李卫平 雷朝霞 郝泽峰 |
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| 作者单位： | 1. 山西医科大学汾阳学院药理学教研室,032200
2. 山西省汾阳医院,032200 |
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| 摘 要： | 目的 :研究附子汤与芍药甘草汤合用的镇痛作用及其机制。方法 :采用福尔马林疼痛模型大鼠 ,观察药物的镇痛作用 ;采用冰醋酸致痛模型小鼠 ,测血清和脊髓中一氧化氮 (NO催化光度法 )、前列腺素E2 (PGE2 )的含量和超氧化物歧化酶 (SOD)活性 (紫外分光光度法 )。结果 :附子汤加芍药甘草汤能抑制福尔马林引起的I相及Ⅱ相疼痛 ,能显著降低冰醋酸疼痛模型小鼠血清中和脊髓中的NO ,PGE2 的含量 ,增加SOD的活性。结论 :附子汤与芍药甘草汤合用对中枢及外周神经末梢均有镇痛作用 ,其镇痛作用与NO ,PGE2 ,SOD有关
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| 关 键 词： | 附子汤 芍药甘草汤 镇痛作用 一氧化氮 前列腺素E2 超氧化物歧化酶 |
Study of monkshood decoction and decoction containing peony and licorice on analgesic functions and of its mechanism |
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| Li Ruiming,Li Weiping Fenyang College of Shanxi Medical University,Fenyang ,Shanxi,China Lei Zhaoxia,Hao Zefeng Fenyang Hospital,Fenyang ,Shanxi,China. Study of monkshood decoction and decoction containing peony and licorice on analgesic functions and of its mechanism[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2002, 11(23): 2323-2325 |
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| Authors: | Li Ruiming Li Weiping Fenyang College of Shanxi Medical University Fenyang Shanxi China Lei Zhaoxia Hao Zefeng Fenyang Hospital Fenyang Shanxi China |
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| Affiliation: | Li Ruiming,Li Weiping Fenyang College of Shanxi Medical University,Fenyang 032200,Shanxi,China Lei Zhaoxia,Hao Zefeng Fenyang Hospital,Fenyang 032200,Shanxi,China |
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| Abstract: | Objective: It is to investigate the analgesic functions and mechanism of monkshood decoction and decoction containing peony and licorice. Methods: The analgesic functions were observed with formalin painful model rats. Nitrous oxide (NO) in blood serum and spinal marrow (NO catalysis photometry), amount of prostaglandin E 2 (PGE 2) and activity of super oxide dismutase (SOD) were determined with ice acetic acid caused pain model mice. Results: The drug could inhibit pains in phase I and phase II resulted from formalin, it also could decrease the amount of NO and PGE 2 in blood serum and spinal marrow in ice acetic acid caused pain model mice and improve the activity of SOD. Conclusion: Monkshood decoction and decoction containing peony and licorice have analgesic functions on central and peripheral nerve endings, and the analgesic function are related to NO, PGE 2 and SOD. |
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| Keywords: | monkshood decoction decoction containing peony and licorice analgesic function nitrous oxide prostaglandin E 2 super oxide dismutase |
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