老年慢性支气管炎患者红细胞免疫功能及其相关细胞因子水平的探讨

目的：探讨了老年慢性支气管炎患者红细胞免疫指标与白细胞介素-4（IL-4）、白细胞介素-5（IL-5）、白细胞介素-8（IL-8）和白细胞介素-10（IL-10）水平的变化。方法：分别应用免疫法、放免法和酶联免疫法对48例老年慢性支气管炎患者进行了红细胞免疫功能及相关的细胞因子测定，并与35名正常健康人作比较。结果：老年慢性支气管炎患者RBC-C3bRR、IL-10水平明显降低（P〈0．01），而IL-4、IL-5、IL-8水平显著升高（P〈0．01），RBC-C3bRR水平与IL-4、IL-5、IL-8呈明显的负相关（r=-0．3112、-0．3415、-0．3718，P〈0．05），RBC-ICRRR水平明显地高于正常人组（P〈0．05）与IL-10水平呈正相关（r=0．3715，P〈0．05）。结论：老年慢性支气管炎患者存在有红细胞免疫调节的紊乱、免疫功能的低下与细胞因子的水平有相关性。

Study on the Red Blood Cell Immuno-Function and Relevant Cytokines Levels in Elderly Patients with Chronic Bronchitis

Objective To explore the changes of red blood cell immuno-function and serum IL-4,IL-5,IL-8,IL-10 levels in elderly patients with chronic bronchitis.Methods The red cell C3b receptor(RBC-C3bR) and red blood cell immune complex rosette(RBC-ICR)(with immune methods),IL-4,IL-8 levels(with RIA) and IL-10,IL-5 levels(with ELISA) were measured were measured in 48 elderly patients with chronic bronchitis and 35 controls.Results RBC-C3bRR percentage and IL-10 levels were significantly lower in patients with chronic bronchitis than those in controls(P<0.01) while IL-4,IL-5,IL-8 levels were significantly higher(P<0.01),RBC-C3bRR was significantly negatively correlated to IL-4,IL-5 and IL-8(r=-0.3112,-0.3415,-0.3718,P<0.05) and RBC-ICRRR was positiviely correlated to IL-10 level(r=0.3715,P<0.05).Conclusion The lower red cell immuno-function is closely associated with alteration of cytokines levels in elderly patients with chronic bronchitis.