| 急性白血病多药耐药相关蛋白及P糖蛋白表达与临床耐药的关系 |
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| 摘 要： |
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| 关 键 词： | 急性白血病 多药耐药相关蛋白 P糖蛋白 免疫组织化学 化疗 |
Expression of multidrug resistance P-170 and MRP and their correlation with clinical drug resistance in acute leukemia] |
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| Authors: | Xiu-mei Lin Zhao-xia Xie Yan Zhu |
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| Institution: | Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To investigate the relevance between the expression of P-170 and MRP and clinical drug resistance in acute leukemia. METHODS: The expression of P-170 and MRP in mononuclear cells of bone marrows was analyzed by the immunohistochemical technique in 72 acute leukemia patients. RESULTS: The expression of P-170 was positive in 46 and negative in 26 of the 72 post-chemotherapy acute leukemia patients. The therapeutic effect of the P-170 positive expression patients was significantly poorer than that of the negative expression patients (P < 0.01). The expression of MRP was positive in 39 and negative in 33 of the 72 post-chemotherapy acute leukemia patients. The therapeutic effect of the MRP positive expression patients was significantly poorer than that in the negative expression patients (P < 0.01). The expression of P-170 and MRP had a significant concordance (Kappa = 0.427, P < 0.01). The sensitivity of P-170 and MRP which were analyzed simultaneously was 97.5%, which was higher than that of P-170 (90%) or MRP (77.5%) analyzed respectively in drug resistance patients. CONCLUSION: The expression of P-170 and/or MRP was significantly related with drug resistance in clinical chemotherapy. The therapeutic effect was significantly poorer in P-170 and/or MRP positive expression patients than that in negative expression patients. These data suggest that P-170 and MRP analyzed simultaneously can improve the value of diagnosis and prognosis in patients with drug resistance leukemia. |
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