Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages. |
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| Authors: | R Manjeet K B Ghosh |
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| Affiliation: | Molecular Immunology and Immunogenetics Laboratory, Centre for Biochemical Technology, Delhi University Campus, India. |
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| Abstract: | High amounts of nitric oxide and TNF-alpha generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-alpha and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium. |
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