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| 雷公藤多甙对大鼠局灶性脑缺血-再灌注损伤脑组织中NO水平、NOS活性的影响 | |
| 引用本文： | 方莉,方伟,李庆军,董海军.雷公藤多甙对大鼠局灶性脑缺血-再灌注损伤脑组织中NO水平、NOS活性的影响[J].郑州大学学报(医学版),2003,38(1):87-89. |
| 作者姓名： | 方莉 方伟 李庆军 董海军 |
| 作者单位： | 1. 郑州大学医院检验科,郑州,450052 2. 河南省建筑医院内科,郑州,450003 3. 郑州大学第一附属医院神经内科研究生,郑州,450003 4. 郑州大学医院药剂科,郑州,450052 |
| 摘 要： | 目的：研究大鼠局灶性脑缺血－再灌注损伤脑组织中一氧化氮（NO）水平，一氧化氮合酶（NOS）活性变化及雷公藤多甙（GTW）对其影响，方法：将100只Wistar大鼠分成假手术组，手术组，生理盐水治疗组和GTW治疗组，用线检法建立大鼠脑缺血－再灌注动物模型，用硝酸银还原法测定4例大鼠脑组织缺血1h再灌注15min,1h,6h,12h,24h,NO含量和NOS活性。结果：与手术组及生理盐水治疗组相比，各时间点GTW治疗组大鼠脑组织NOS活性降低，NO含量减少（P＜0．05）。结论：GTW对大鼠局灶性脑缺血－再灌注损伤有保护作用。 |
| 关 键 词： | 雷公藤多甙 局灶性脑缺血 缺血再灌注损伤 脑缺血－再灌注 一氧化氮 一氧化氮合酶 |
| 修稿时间： | 2002年4月28日 |
Changes of NOS and NO in tissues of focal cerebral ischemia-reperfusion injury in rats and effects of multi-glycosides of TWHF on them |
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| FANG Li,FANG Wei,LI Qingjun,DONG Haijun Clinical Laboratory,Zhengzhou University s Hospital,Zhengzhou.Changes of NOS and NO in tissues of focal cerebral ischemia-reperfusion injury in rats and effects of multi-glycosides of TWHF on them[J].Journal of Zhengzhou University: Med Sci,2003,38(1):87-89. | |
| Authors: | FANG Li FANG Wei LI Qingjun DONG Haijun Clinical Laboratory Zhengzhou University s Hospital Zhengzhou |
| Institution: | FANG Li,FANG Wei,LI Qingjun,DONG Haijun1) Clinical Laboratory,Zhengzhou University s Hospital,Zhengzhou 450052 2 ) Department of Internal Medicine,the Hospital of Constructive Company of Henan Province,Zhengzhou 450003 3 ) Department of Neurology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 4 ) Department of Pharmacy,Zhengzhou University s Hospital,Zhengzhou 450052 |
| Abstract: | Aim:To study the changes of NOS and NO in tissues of focal cerebral isehemia-reperfusion injury in rats and the effects of multi-glycosides of TWHF (GTW) on them. Methods; A total of 100 Wistar rats were allocated into 4 groups: the sham-operation group, the operation group, the group treated by normal saline and the group treated by GTW. Cerebral isehemia-reperfusion injury model was established with suture method. NO and NOS were determined with method of silver nitrate deoxidization after 1h ischemia and reperfusion 15 mins, 1 h, 6 h, 12 h,and 24 h. Results:Compared to the operation group and the group treated by normal saline,at varied moments,the activity of NOS and the content of NO in group treated by GTW decreased (P <0. 05). Conclusion; GTW has protective effect on focal cerebral ischemia-reperfu-sion injury in rats. |
| Keywords: | ischemia-reperfusion NO NOS multi-glycosides of TWHF rat |
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