Comparison of pharmacokinetics of lanoteplase and alteplase during acute myocardial infarction |
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| Authors: | Kostis John B Dockens Randy C Thadani Udho Bethala Vasnath Pepine Carl Leimbach Wayne Vachharajani Nimish Raymond Ralph H Stouffer Bruce C Tay Lee K Shyu Wen Chyi Liao Wei-chi |
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| Institution: | Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA. |
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| Abstract: | OBJECTIVE: Lanoteplase is a rationally designed variant of tissue plasminogen activator. The aim of this study was to examine the pharmacokinetics and functional activity of a single intravenous bolus dose of lanoteplase with those of a bolus plus two-step infusion of alteplase. DESIGN: Seven-centre substudy of the InTIME-I angiographic trial in patients presenting within 6 hours of onset of suspected acute myocardial infarction. PATIENTS AND PARTICIPANTS: A total of 31 patients (28 males, 3 females) enrolled in this substudy mean age 59 (range 26 to 76) years]. METHODS: Twenty-three patients randomised to lanoteplase received single bolus doses of 15 kU/kg (n = 5), 30 kU/kg (n = 3), 60 kU/kg (n = 9), or 120 kU/kg (n = 6). Eight patients received alteplase
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