体表测量计算漏斗胸大鼠胸腔容积的研究

目的：通过体表测量计算胸腔容积评价肺发育、胸廓缩小程度及漏斗胸畸形程度。方法将90只健康4周龄SD大鼠分成实验组和对照组，实验组70只，对照组20只。实验组从胸骨旁切断下位3对肋软骨制作漏斗胸大鼠模型。分别于术前，术后2、4、8、12周测量胸部多条径线，并进行组间比较。胸腔容积大小用数学公式计算，利用阿基米德原理测量及C T三维重建所得，采用SPSS17．0进行 t检验及直线回归分析。结果实验采用多条径线测量结果，经过数学计算，阿基米德原理测量，以及CT三维重建所得结果实验组与对照组比较，差异有统计学意义（P＜0．05）。结论通过体表测量计算胸腔容积的方法是可行的，该方法可替代CT检查对于评估漏斗胸形成过程中的胸腔容积的改变。

The research of surface measurement in calculating chest volume of pectus excavatum rats

Objective To calculate the chest volume for an evaluation of lung development ,the degree of thorax narrowing and pectus excavatum deformity by the surface measurements .Methods Ninety normal Sprague Dawley (4 weeks) rats were ran‐domly divided into experimental and control groups .Experimental group had 70 rats and control group had 20 rats .Cutting off the lower three cartilage from parasternal of rats to produce Pectus excavatum model in experimental groups .We measured many chest radial lines before surgery ,2 ,4 ,8 and 12 weeks after surgery respectively ,then made comparison between parallel group .Thoracic volume size was calculated by a mathematical formula ,Archimedes measurement and the CT three dimensional reconstruction ,and the t test and linear regression were analyzed by SPSS17 .0 .Results this experiment used multiple radial lines to get measurement results ,and through mathematical calculations ,Archimedes measurement and CT reconstruction ,we found there were significant differences between the experimental group and the control group (P<0 .05) .Conclusion It is practicable of surface measurement to calculate chest volume .This method could replace the CT examination to evaluate the change of the chest volume along the process of pectus excavatum formation .