| 1－（2，6－二甲基苯氧基）－2－（3，4－二甲氧基苯乙氨基）丙烷盐酸盐对培养心肌细胞缺氧后再给氧损伤的影响 |
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| 引用本文： | 高明堂,钱家庆.1－（2，6－二甲基苯氧基）－2－（3，4－二甲氧基苯乙氨基）丙烷盐酸盐对培养心肌细胞缺氧后再给氧损伤的影响[J].中国药理学通报,1995(5). |
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| 作者姓名： | 高明堂 钱家庆 |
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| 作者单位： | 同济医科大学药理教研室，兰州医学院药理教研室 |
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| 摘 要： | 采用离体培养大鼠乳鼠心肌细胞，研究了１－（２，６－二甲基苯氧基）－２－（３，４－二甲氧基苯乙氨基）丙烷盐酸盐（ＤＤＰＨ）对培养心肌细胞缺氧后再给氧损伤的影响。ＤＤＰＨ１～１０μｍｏｌ·Ｌ－１可使缺氧后再给氧心肌细胞搏动能基本维持正常，乳酸脱氨酶释放有所减少，细胞成活率提高，减少心肌细胞膜损伤。其作用与Ｖｅｒａｐａｍｉｌ具有相似之处。表明ＤＤＰＨ对缺氧与再给氧心肌细胞具有保护作用。
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| 关 键 词： | 1－（2，6－二甲基苯氧基）－2－（3，4－二甲氧基苯乙氨基）丙烷盐酸盐 乳酸脱氢酶 培养心肌细胞 缺氧 |
Effect of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride on cultured myocytes anoxia/reoxygenation injuries |
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| GAO Ming-Tang,QIAN Jai-Qing.Effect of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride on cultured myocytes anoxia/reoxygenation injuries[J].Chinese Pharmacological Bulletin,1995(5). |
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| Authors: | GAO Ming-Tang QIAN Jai-Qing |
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| Abstract: | The effect of 1-(2, 6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride (DDPH) on reoxygenation damages were studied on cultured myocytes from neonatal rat hearts. 30 min before anoxia, addition of DDPH 1～10 μmol·L-1 increased the beat rate and survival rate of myocardial cells,decreased the relrase of lactate dehydrogenase(LDH) from myocytes and the myocardial ultrastructure was normal during anoxia/reoxygenation. These results suggested that DDPH may provide some protecive effects on the anoxia/reoxygenation damages on myocardium. |
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| Keywords: | DDPH LDH cultured myocytes anoia |
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