奥卡西平单药及联合用药治疗部分性癫痫发作23例疗效分析

目的：观察奥卡西平单药及合并其他抗癫痫药物治疗部分性癫痫的临床疗效及安全性。方法：对临床诊断为部分性癫痫的患者共23例（单纯部分性发作3例，复杂部分性发作13例，部分发作继发全身发作7例），采用单药或联合用药治疗，观察治疗前后癫痫发作频率的变化，同时观察用药前后脑电图变化和药物的不良反应。结果：单药治疗组发作频率减少81．09％，总有效率为80．00％；联合用药治疗组发作频率减少82．84％，总有效率为84．61％，用药前后脑电图明显好转者6例，发作严重程度明显减轻，有2例患者用药后有轻度头晕，未见其他明显不良反应。结论：奥卡西平单用及联合其他抗癫痫药物治疗癫痫部分性发作获得满意的临床疗效，且不良反应轻，有较高的临床应用价值。

The clinical effect of Oxcarbazepine alone and combining with other anti-epileptic drugs on 23 cases of partial seizures

Objective To investigate the clinical effect and safety of Oxcarbazepine alone and combining with other anti-epileptic drugs in the treatment of patients with partial seizures. Mehtod Twenty-three patients with partial seizures, including 3 cases of singlet partial seizures, 13 cases of complex partial seizures and 7 cases of partial seizure, were randomly divided into two groups. One group was given Oxcarbazepine only, the other group accepted Oxcarbazepine combining with other anti-epileptic drugs. The diversity of the seizure frequency before and after treatment, the diversity of electroencephalogy and the side effects of drugs were observed. Results The seizure frequency of Oxcarbazepine group reduced by 81.09%, and the total effective rate was 80.00%. The seizure frequency of combining with other anti-epileptic drugs group reduced by 82.84%, and the total effective rate was 84.61%. The electroencephalogy of 6 cases with combining therpy was improved obviously, and the severity level was relieved significantly. 2 cases of this group got slightly dizzy, but with no other side effects. Conclusion Both Oxcarbazepine alone and combining with other anti-epileptic drugs can have satisfactory effects in treating partial seizures, show slight side effects, and may have a great clinical application value.