| TSG101在胰腺癌组织的表达及临床意义 |
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| 引用本文： | 闫曦,王燕,费晋秀.TSG101在胰腺癌组织的表达及临床意义[J].细胞与分子免疫学杂志,2011,27(4):433-434. |
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| 作者姓名： | 闫曦 王燕 费晋秀 |
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| 作者单位： | 解放军第323医院消化科,陕西西安,710056 |
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| 摘 要： | 目的:检测肿瘤易感基因101(TSG101)在胰腺癌组织中表达水平及其与癌患者临床病理特征的关系。方法:应用免疫组织化学方法检测TSG101蛋白在胰腺癌及其对应正常胰腺组织的表达情况,并分析其在肿瘤中表达水平与患者性别、分化、临床分期及转移等临床病理资料之间的相关性。结果:TSG101在胰腺肿瘤组织中表达率为47/58(81.0%)明显高于正常胰腺组织表达率7/58(12.1%)(P<0.05),统计学分析提示TSG101在胰腺癌组织表达率明显高于正常胰腺组织(P<0.05),在高分化胰腺癌组织中表达明显强于中、低分化肿瘤组织,在转移性胰腺癌中表达率高于非转移性肿瘤组织(P<0.05),而与患者性别及临床分期间差异无统计学意义(P>0.05)。结论:TSG101在胰腺癌组织中表达与其分化程度及转移呈正相关。
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| 关 键 词： | TSG101 胰腺癌 免疫组织化学 分化 |
Expression of TSG101 and its clinical significance in pancreatic cancer |
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| YAN Xi,WANG Yan,FEI Jin-xiu.Expression of TSG101 and its clinical significance in pancreatic cancer[J].Journal of Cellular and Molecular Immunology,2011,27(4):433-434. |
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| Authors: | YAN Xi WANG Yan FEI Jin-xiu |
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| Institution: | YAN Xi,WANG Yan,FEI Jin-xiu Department of Digestive Diseases,323 Hospital of PLA,Xi'an 710056,China |
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| Abstract: | AIM:To investigate the expression of TSG101 in pancreatic cancer and matched noncancer tissues,and analyze the relationships between its expression in cancer tissues with clinical data.METHODS: Immunohistochemisty was performed to measure the expression of TSG101 in pancreatic cancer and matched noncancer tissues,and analyze its association with clinicopathological data including gender,differentiation,TNM staging and metastasis.RESULTS: TSG101 showed a significantly higher expression rate in total tumor ti... |
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| Keywords: | TSG101 pancreatic cancer immunohistochemistry differentiation |
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