| 针刺对AlCl3致痴呆大鼠空间记忆障碍的改善作用 |
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| 引用本文： | 赵惠玲,丁茂超,胡斯旺,戴开宇,陈忠孝,陈世新.针刺对AlCl3致痴呆大鼠空间记忆障碍的改善作用[J].温州医学院学报,2011,41(1):10-12. |
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| 作者姓名： | 赵惠玲 丁茂超 胡斯旺 戴开宇 陈忠孝 陈世新 |
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| 作者单位： | 1. 温州医学院,实验动物中心,浙江,温州,325035
2. 温州医学院,人体解剖学教研室,浙江,温州,325035 |
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| 基金项目： | 浙江省教育厅科研基金资助项目(Y200803166); 温州市科技局科研基金资助项目(Y20070055) |
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| 摘 要： | 目的：观察针刺对AlCl3致阿尔茨海默病（Alzheimer’s disease,AD）大鼠空间记忆障碍的改善作用并探讨其可能机制。方法：采用AlCl3灌胃制作AD大鼠模型,Morris水迷宫检测大鼠空间记忆能力,免疫印迹检测tau蛋白磷酸化水平。结果：针刺能明显缩短大鼠寻找平台的时间,降低tau蛋白磷酸化水平。结论：针刺能有效改善因AlCl3所致的大鼠空间记忆障碍,其机制可能与抑制tau蛋白过度磷酸化有关。
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| 关 键 词： | 阿尔茨海默病 记忆障碍 针刺 tau蛋白质类 大鼠 |
Effects of acupunture on spatial memory and its mechanism to AD rats induced by AlCl3 |
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| ZHAO Huiling,DING Maochao,HU Siwang,DAI Kaiyu,CHEN Zhongxiao,CHEN Shixin.Effects of acupunture on spatial memory and its mechanism to AD rats induced by AlCl3[J].Journal of Wenzhou Medical College,2011,41(1):10-12. |
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| Authors: | ZHAO Huiling DING Maochao HU Siwang DAI Kaiyu CHEN Zhongxiao CHEN Shixin |
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| Institution: | ZHAO Huiling,DING Maochao,HU Siwang,DAI Kaiyu,CHEN Zhongxiao,CHEN Shixin.Laboratory Ani-mal Science Center,Wenzhou Medical College,Wenzhou,325035 |
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| Abstract: | Objective: To observe the spatial memory impact of acupuncture to AD(Alzheimer's disease,AD) rats and discuss the mechanism.Methods: The AD model was established by AlCl3.Spatial memory retention and tau protein were detected by Morris and Western blot.Results: It was shown that the acupuncture can shorten the time to find the platform and decrease the tau hyperphosphorylation level.Conclusion: Acupuncture may effectively prevent the rats from AlCl3-induced spatial memory deficits by inhibiting tau hyperpho... |
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| Keywords: | spatial memory acupuncture tau protein rat |
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