| PAR-2在人胰腺肿瘤细胞中的表达及其相关机制的研究 |
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| 引用本文： | 刘星,胡煜辉,肖游章,张晓春,周青,李晓飞.PAR-2在人胰腺肿瘤细胞中的表达及其相关机制的研究[J].细胞与分子免疫学杂志,2011,27(4):430-432. |
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| 作者姓名： | 刘星 胡煜辉 肖游章 张晓春 周青 李晓飞 |
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| 作者单位： | 1. 井冈山大学医学院
2. 吉安市中心人民医院手术室,江西,吉安,343000 |
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| 基金项目： | 吉安市科技局指导性科技计划项目(2010年度); 井冈山大学2010年校级自然科学科研项目(JZ10022) |
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| 摘 要： | 目的:通过对蛋白酶激活受体-2(PAR-2)在人胰腺癌细胞及癌旁组织中表达态势的研究,以期明确PAR-2在胰腺癌中表达特点,并探索其相关机制。方法:收集胰腺癌标本,采用免疫组织化学(SP法)检测胰腺癌PAR-2基因的表达;培养胰腺癌细胞,采用逆转录聚合酶链式反应(RT-PCR)检测胰腺癌PAR-2基因的表达。结果:胰腺癌组PAR-2 mR-NA的表达高于对照组(P<0.01)。PAR-2在胰腺癌中的表达与患者年龄、性别无关(P>0.05),但癌细胞远处转移者显著高于无转移者(P<0.01)。结论:胰腺癌的发生与发展与PAR-2正相关。PAR-2在胰腺癌中的表达与患者年龄、性别无关;但与淋巴结转移正相关。
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| 关 键 词： | 胰腺癌 蛋白酶激活受体-2 SP法 逆转录聚合酶链式反应 表达 |
Study about expression of proteinase activated receptor-2 in human pancreatic cancer cells and its related mechanism |
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| LIU Xing,HU Yu-hui,XIAO You-zhang,ZHANG Xiao-chun,ZHOU Qing,LI Xiao-fei.Study about expression of proteinase activated receptor-2 in human pancreatic cancer cells and its related mechanism[J].Journal of Cellular and Molecular Immunology,2011,27(4):430-432. |
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| Authors: | LIU Xing HU Yu-hui XIAO You-zhang ZHANG Xiao-chun ZHOU Qing LI Xiao-fei |
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| Institution: | LIU Xing,HU Yu-hui,XIAO You-zhang,ZHANG Xiao-chun,ZHOU Qing,LI Xiao-fei Medical College of Jinggangshan University,Ji'an 343000,China |
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| Abstract: | AIM:By observing expression of PAR-2 in human pancreatic cancer cells and cancer tissue adjacent.In order to clear of expression characteristic of PAR-2 in pancreatic cancer and explore relevant mechanism.METHODS: Collect pancreatic specimens and adopting method of SP to detect expression of pancreatic cancer PAR-2 gene.Cultivate pancreas cancer cells and adopting RT-PCR detection expression of PAR-2 gene in pancreatic cancer.RESULTS: PAR-2 mRNA expression of pancreatic cancer group higher than control greu... |
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| Keywords: | pancreatic cancer PAR-2 method of SP RT-PCR expression |
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