Dithranol (anthralin) versus triacetoxyanthracene |
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| Authors: | WOLFGANG P. RAAB |
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| Affiliation: | Department of Medical Chemistry, Vienna University Medical School, Waehringerstrasse 10, A-1090 Vienna, Austria |
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| Abstract: | In two in vitro models for evaluating antipsoriatic activity, dithranol (anthralin) and triacetoxyan-thracene were compared. Both compounds exhibited an about equal effect on oxygen consumption of surviving human skin. Dithranol, however, exerted a stronger inhibiting effect on gIucose-6-phos-phate dehydrogenase (G-6-PDH) activity of human skin homogenates. |
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