| 锂-匹鲁卡品大鼠急性癫痫模型的建立及评价 |
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| 引用本文： | 张军强,赵红宁,王晓明,黄敏,余巨明. 锂-匹鲁卡品大鼠急性癫痫模型的建立及评价[J]. 川北医学院学报, 2007, 22(6): 537-539 |
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| 作者姓名： | 张军强 赵红宁 王晓明 黄敏 余巨明 |
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| 作者单位： | 川北医学院附属医院神经内科,四川,南充,637000;川北医学院附属医院神经内科,四川,南充,637000;川北医学院附属医院神经内科,四川,南充,637000;川北医学院附属医院神经内科,四川,南充,637000;川北医学院附属医院神经内科,四川,南充,637000 |
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| 基金项目： | 四川省杰出青年学科带头人培养计划 |
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| 摘 要： | 目的用氯化锂-匹鲁卡品制备Wistar大鼠急性癫痫模型,探讨匹鲁卡品合适的剂量及用法。方法54只wistar大鼠腹腔注射氯化锂3 mmol/kg,在三天内分六个时间段给予不同剂量的匹鲁卡品腹腔注射。结果30只大鼠癫痫持续状态(SE)发作,5只死亡,以氯化锂预处理16小时-24小时后注射30 mg/kg匹鲁卡品量组的SE发作率高,死亡率低。结论用氯化锂-匹鲁卡品制备Wistar大鼠SE模型,氯化锂预处理16小时-24小时后注射30 mg/kg匹鲁卡品量较好。
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| 关 键 词： | 癫痫持续状态 氯化锂 匹鲁卡品 |
| 文章编号： | 1005-3697（2007）06-0537-03 |
| 修稿时间： | 2007-09-26 |
Establishment and Appraisement of Lithium-pilocarpine Induced Rat Model of Acute Epilepsy |
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| ZHANG Jun-qiang,ZHAO Hong-ning,WANG Xiao-ming,HUANG Min,YU Ju-ming. Establishment and Appraisement of Lithium-pilocarpine Induced Rat Model of Acute Epilepsy[J]. Journal of North Sichuan Medical College, 2007, 22(6): 537-539 |
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| Authors: | ZHANG Jun-qiang ZHAO Hong-ning WANG Xiao-ming HUANG Min YU Ju-ming |
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| Affiliation: | Department of Neurology, the Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China |
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| Abstract: | Objective To identify the appropriate dose and method of pilocarpin in the lithium-pilocarpine induced rat model of acute epilepsy.Methods 54 Wistar rats were injected abdominally with lithium by 6 different periods later within 3 days,different dose of pilocarpin was injected.Results 30 rats were induced successfully to status epileptieus in al1,5 rats were dead.In the groups injected with 30 mg/kg after 16-24 hours,have the high ratio of SE and low death ratio.Conclusion In the lithium-pilocarpine induced rat model of acute epilepsy,it is better to be injected with 30 mg/kg 16-24 hours later. |
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| Keywords: | Status epilepticus Lithium Pilocarpine |
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