甲基莲心碱对光化学诱导大鼠脑缺血损害的保护作用

目的：探讨甲基莲心碱对脑缺血的保护作用。方法：应用光化学诱导大鼠大脑中动脉栓塞（MCAO）模型，观察预防性使用甲基莲心碱对脑梗死患者，梗死区脑组织H2O，Ca^2 ，NO，丙二醛（MDA）含量以及超氧化物歧化酶（SOD）活力的影响。结果：光化学反应6h后，脑梗死范围占同侧半球体积的（20.9＋4.3）％，梗死区脑组织Ca^2 ,H2O,MDA含量增高而NO水平和SOD活力下降。预防性给予甲基莲心碱可缩小脑梗死面积，同时增加梗死区脑组织NO水平和SOD活力，降低Ca^2 ,H2O,DMA含量。结论：甲基莲心碱具有减轻大鼠脑缺血的作用，其机制可能与对抗脑缺血时NO，Ca^2 的病理性改变有关。

Protective effect of neferine on ischemic brain damage induced by photochemistry

AIM: To study the effects of neferine (Nef) on ischemic brain damage induced by photochemistry in rats. METHODS: The rat model of middle cerebral artery occlusion (MCAO) was induced by photochemistry and the contents of H 2O, Ca 2 and MDA as well as NO level and superoxide dismutase (SOD) activity were measured. RESULTS: Six hours after MACO induced by photochemistry, cerebral ischemia was formed, NO level and SOD activity were decreased. However, the contents of H 2O,Ca 2 and MDA were increased. Nef reduced the ischemic areas of brain, decreased contents of Ca 2 , H 2O and MDA. Furthermore, Nef also increased NO level and SOD activity of brain. CONCLUSION: Decrease of NO level and Ca 2 overload are important factors leading to ischemic brain damage. Nef can be used to protect ischemic brain damage by influencing pathological changes of NO and Ca 2 level.