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Asscessment of the clinical value of CK-M2 and oligosaccharide protein inserum from patients with gastric carcinoma |
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| Authors: | Gui Lan Zhao Jie Lin Shu You Peng Qi Yun Li Fan Zhou Xian Sheng Chen Xin You Xie Yi Xiong Zheng |
| Institution: | 1. Department of Surgery, the Second Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, Zhejiang Province, China 2. Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310009, Zhejiang Province, China 3. Department of Surgery, the Second Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, Zhejiang Province, China |
| Abstract: | AIM To evaluate the clinical value of creatine kinase macroisoenzyme type 2 (CK-M2) and oligosaccharideprotein (OP) in serum from patients with gastric carcinoma (GC).METHODS Serum level of CK-M2 was detected by agar gel electrophoresis. OP concentration was measuredby an enzyme immunoassay.RESULTS Serum levels of CK-M2 and OP in 57 cases of GC were significantly higher than those in 51 caseswith gastric precancerous lesion and 28 controls. The diagnostic sensitivity and specificity for GC with CK-M2 was 56.10% and 98.63% respectively. CK-M2 and OP were not associated with histologic type and degreeof differentiation.CONCLUSION These results suggest that CK-M2 may serve as a marker to diagnose GC, and the specificityis higher, whereas OP is not more significant for GC diagnosis, but it could be a useful indicator forevaluation the status of body immune. |
| Keywords: | stomach neoplasms serodiagnosis oligosaccharides creatine kinase isoenzymes electrophoresis agar gel immunoenzyme techniques |
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