| 7-氮杂吲哚-3-羧酸的合成工艺改进 |
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| 引用本文： | 蒋骏航,吕加国,周有骏. 7-氮杂吲哚-3-羧酸的合成工艺改进[J]. 药学实践杂志, 2007, 25(5): 312-314,345 |
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| 作者姓名： | 蒋骏航 吕加国 周有骏 |
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| 作者单位： | 第二军医大学药学院药物化学教研室,上海,200433 |
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| 摘 要： | 目的:改进7-氮杂吲哚-3-羧酸的合成工艺。方法:以丁二腈为起始原料,用四氢呋喃、乙酸乙酯、石油醚等代替了原工艺中的异丙醚,正庚烷,氯苯等,并对处理工艺进行了优化。结果:优化后的制备工艺成本低,毒性小,后处理方便,提高了产率。结论:新工艺总产率达到43.4%,更适合工业生产。
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| 关 键 词： | 7-氮杂吲哚-3-羧酸 合成 工艺改进 |
| 文章编号： | 1006-0111（2007）05-0312-04 |
| 收稿时间： | 2007-03-21 |
| 修稿时间： | 2007-03-04 |
Improvement of the synthetic process of 7-azaindol-3-carboxylic acid |
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| JIANG Jun-hang,Lü Jia-guo,ZHOU You-jun. Improvement of the synthetic process of 7-azaindol-3-carboxylic acid[J]. The Journal of Pharmaceutical Practice, 2007, 25(5): 312-314,345 |
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| Authors: | JIANG Jun-hang Lü Jia-guo ZHOU You-jun |
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| Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Objective: To improve the synthetic process of 7-azaindol-3-carboxylic acid.Methods: The succinonitrile was taken as the original raw material.The isopropyl ether,n-heptane,and chlorobenzene, which were used in original technics,were subsituted by ethyl acetate,petroleun ether,and xylene respectively.The disposition technics was optimized.Results: The technics was successfully improved due to its low cost,small toxicity,convenient disposition and high yield.Conclusions: The higher overall yields was 43.4%.This improved method is more suitable for industrial production for its low cost. |
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| Keywords: | 7-Azaindol-3-carboxylic acid synthesis technical improvement |
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