| 基质金属蛋白酶-9/C1562T基因多态性与缺血性脑卒中的关系 |
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| 引用本文： | 张丽,张颖冬,李继民,张晓雷. 基质金属蛋白酶-9/C1562T基因多态性与缺血性脑卒中的关系[J]. 临床神经病学杂志, 2008, 21(6) |
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| 作者姓名： | 张丽 张颖冬 李继民 张晓雷 |
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| 作者单位： | 南京医科大学附属脑科医院老年神经科,210029 |
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| 摘 要： | 目的探讨基质金属蛋白酶-9(MMP-9)启动子基因C1562T多态性与缺血性脑卒中(IS)的关系。方法采用聚合酶链式反应-限制性片段长度多态性分析(PCR-RFLP)法检测114例IS患者(IS组)及80名正常对照者(NC组)MMP-9/C1562T基因型和等位基因频率,分析其与IS发病的相关性。结果IS组与NC组间MMP-9/C1562T基因型及等位基因频率差异无统计学意义(P>0.05)。结论MMP-9/C1562T多态性可能与IS的发病无关。
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| 关 键 词： | 基质金属蛋白酶-9 基因多态性 缺血性脑卒中 |
Relationship between the gene polymorphism of matrix metalloproteinase-9/C1562T and ischemic stroke |
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| ZHANG Li,ZHANG Ying-dong,LI Ji-min,et al.. Relationship between the gene polymorphism of matrix metalloproteinase-9/C1562T and ischemic stroke[J]. Journal of Clinical Neurology, 2008, 21(6) |
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| Authors: | ZHANG Li ZHANG Ying-dong LI Ji-min et al. |
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| Affiliation: | ZHANG Li,ZHANG Ying-dong,LI Ji-min,et al. Department of Neurology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Objective To investigate the relationship between the gene polymorphisms of matrix metalloproteinase (MMP)-9/C1562T and ischemic stroke (IS). Methods The frequencies of genotype and allele of MMP-9/C1562T gene were detected by PCR-RFLP in 114 patients with IS(IS group) and 80 normal controls(NC group). The correlation analysis was taken between the results and incidence of IS. Results The frequencies of genotype and allele of MMP-9/C1562T were no significant difference between the groups IS and NC (P>0.05).Conclusion The gene polymorphism of MMP-9/C1562T may be unrelated with IS. |
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| Keywords: | matrix metalloproteinase-9 polymorphism ischemic stroke |
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