高聚金葡素联合顺铂治疗恶性胸腔积液临床观察

目的观察高聚金葡素(简称金葡素)联合顺铂(DDP)胸腔内给药治疗恶性胸腔积液的近期疗效和不良反应。方法经病理学、细胞学证实的恶性胸腔积液47例,采用中心静脉导管行胸腔引流术排尽胸腔积液后,随机分为两组。治疗组(A组,n=27):采用胸腔内注入顺铂及金葡素制剂;对照组(B组,n=20):采用胸腔内注入顺铂。金葡素每次注入4000单位,顺铂每次注入60mg,每周注射1次,连续注射3周后复查。结果治疗组总有效率81.5%,对照组总有效率55.7%。治疗中不良反应主要为恶心、呕吐、发热和胸痛不适,治疗组不良反应发生率为46.1%,对照组为47.6%,两组差异无统计学意义(P0.05)。结论顺铂联合金葡素胸腔内灌注治疗恶性胸腔积液与单药顺铂比较,有较好的疗效,且不增加不良反应,值得临床推广使用。

Curative effect observation of highly agglutinative staphylococcin plus cisplatin in treatment of malignant hydrothorax

Objective To evaluate the effect of combination therapy of highly agglutiative staphylococcin（HAS） plus cisplatin（DDP） in the treatment of malignant hydrothorax.Methods Forty-seven patients with malignant hydrothorax diagnosed by pathology and cytology after drainaging hydrothorax were randomly divided into two groups：group A（n=27,treatmented by HAS plus DDP） and group B（n=20,treated by DDP）,once weekly by thorax cavity injection of 4000U HAS or cisplatin 60mg respectively.The treatment course was 3 weeks.Results The effective rates in group A and B were 81.5% and 55.7% respectively.The adverse effects were nausea,vomitting,fever,chest pain,the adverse effect rates were 46.1% and 47.6% in the group A and B respectively（P〉0.05）.Conclusion The combination therapy of HAS plus DDP can effectively control malignant hydrothorax without increasing the adverse effects and with better therapy effects,which can be worthy of being spread in clinic.