| 进展期胃癌术后化疗联合调强适形放疗的临床观察 |
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| 引用本文： | 陈伟,于壮. 进展期胃癌术后化疗联合调强适形放疗的临床观察[J]. 青岛医药卫生, 2010, 42(6): 401-405. DOI: 10.3969/j.issn.1006-5571.2010.06.001 |
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| 作者姓名： | 陈伟 于壮 |
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| 作者单位： | 1. 青岛大学医学院附属市立医院,266011
2. 青岛大学医学院附属医院 |
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| 摘 要： | 目的观察进展期胃癌术后化疗联合调强适形放疗技术对进展期胃癌的疗效和安全性。方法行胃全切或胃次全切除加淋巴结扩大清扫术（D2）的临床分期为Ⅱ-Ⅲ期胃腺癌37例,采用直线加速器6MV-X线调强适形放疗外照射,处方剂量45Gy/25次,同时在放疗的第1天和第1-14天给予奥沙利铂（艾恒）（120mg/m^2）和卡培他滨（希罗达）（1650mg/m^2）方案化疗,每3周重复,共2疗程。休息2-4周,再予全身化疗2-4周期。结果 2年总生存率为89.8%,2年无瘤生存率84.2%;肝转移3例（8.1%）,腹膜转移2例（5.4%）,吻合口复发1例（2.7%）,腹膜后淋巴结转移1例（2.7%）;根据剂量体积直方图（DVH）评价,95%临床靶区接受了45Gy的照射剂量,OAR受量均在耐受剂量以下。结论进展期胃癌术后化疗联合调强适形放疗是有效的治疗方法,局部控制率较好,无严重毒副反应,病人耐受良好。
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| 关 键 词： | 胃肿瘤 药物疗法 放射治疗 调强适形放疗技术 剂量体积直方图 |
Clinical Observation of Chemotherapy Combined with Intensity Modulated Radiation Therapy for Advanced Gastric Cancer Postoperation |
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| Chen Wei,et al.. Clinical Observation of Chemotherapy Combined with Intensity Modulated Radiation Therapy for Advanced Gastric Cancer Postoperation[J]. QINGDAO Medical Journal, 2010, 42(6): 401-405. DOI: 10.3969/j.issn.1006-5571.2010.06.001 |
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| Authors: | Chen Wei et al. |
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| Affiliation: | Chen Wei,et al.The Affiliated Qingdao Municipal Hospital of Medical College Qingdao University.Qingdao,266011 |
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| Abstract: | Objective To evaluate the safety and efficacy of the chemotherapy combined with intensity modulated radiation therapy(IMRT) for advanced gastric cancer.Methods Thirty-seven patients of advanced gastric cancer with total or subtotal gastrectomy and D2 dissection were irradiated with a total dose of 45Gy of IMRT in 25 fractions by linac with 6-MV photons.All patients received concomitant chemotherapy with two cycles of oxaliplatin(120mg/m2) d1 and capecitabine(1650mg/m2) d1-14.Results The overall survival and... |
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| Keywords: | Gastric cancer Chemotherapy Radiotherapy Intensity modulated radiation therapy Dose volume histogram |
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