| 联合化疗加粒细胞集落刺激因素动员外周造血干细胞的作用 |
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| 引用本文： | 罗以,何执鼎,吴扬,杜娟,张萍,孙忠义,周芳.联合化疗加粒细胞集落刺激因素动员外周造血干细胞的作用[J].中国癌症杂志,2001,11(2):151-152. |
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| 作者姓名： | 罗以 何执鼎 吴扬 杜娟 张萍 孙忠义 周芳 |
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| 作者单位： | 湖南省肿瘤医院内科, |
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| 摘 要： | 目的研究大剂量联合化疗(HDCT)加粒细胞集落刺激因子(G-CSF)对外周血造血干细胞的动员作用。方法8例非霍奇金淋巴瘤(NHL)多周期诱导化疗达完全缓解后，采用大剂量联合化疗，联合应用小剂量G-CSF进行外周造血干细胞的动员。结果动员后外周血WBC及MNC总数明显增加，与动员前比较，差异有显著性。冷冻前后，MNC计数、GFU-G集落总数无明显差异。预处理后，病人中性粒细胞、血小板恢复时间分别平均为(10.5±4)天及(11.5±6)天。结论大剂量联合化疗加小剂量G-CSF联合动员方案是安全有效的，值得推广。
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| 关 键 词： | 造血祖细胞 大剂量化疗 造血细胞生长因子 HDCT G－CSF 非霍奇金淋巴瘤 |
| 文章编号： | 1007-3639(2001)02-0151-02 |
| 修稿时间： | 2000年6月28日 |
Effect of peripheral blood stem cells mobilization by high-dose combination chemotherapy plus low-dose G-CSF after inductive chemotherapy |
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| LUO Yi,HE Zhi-ding,WU Yang,et al.Effect of peripheral blood stem cells mobilization by high-dose combination chemotherapy plus low-dose G-CSF after inductive chemotherapy[J].China Oncology,2001,11(2):151-152. |
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| Authors: | LUO Yi HE Zhi-ding WU Yang |
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| Abstract: | Purpose：To explore the effect of high-dose combination chemotherapy and low dose G-CSF on peripheral blood stem cell (PBSC) mobilization. Methods：After inductive chemotherapy, the peripheral blood stem cells in the eight patients of non-Hodgkin's lymphoma (NHL) with complete remission were mobilized by high-dose combination chemotherapy and low-dose G-CSF. Results：The WBC and MNC counts were increased significantly in post-mobilization. The MNC and GFU-G counts were unchanged regardless of pre-freezed or post-freezed conditions. After the patients were pre-treated, the recovery time of neutrophil and platelet were (10.5±4) days and (11.5±6) days.Conclusions：The mobilizing regimen of high-dose combination chemotherapy and low-dose G-CSF is effective and safe, and can be clinically used. |
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| Keywords: | hematopoietic progenitor cell high dose chemotherapy hematopoietic growth factor |
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