Inputs from the olfactory bulb and olfactory cortex to the entorhinal cortex in the cat |
| |
Authors: | Room P Groenewegen H J Lohman A H M |
| |
Institution: | (1) Department of Anatomy, Vrije University, v. d. Boechorststraat 7, NL-1081 BT Amsterdam, The Netherlands |
| |
Abstract: | Summary The spatial organization and laminar distribution of projections from the olfactory bulb and the anterior (PPCa) and posterior (PPCp) divisions of the prepiriform cortex to the entorhinal cortex were studied with anterograde (3H-leucine) and retrograde (WGA-HRP) tracing techniques. After 3H-leucine injections into the olfactory bulb transported labeling was seen over the lateral entorhinal area, except its most medial part, and over the rostral part of the medial entorhinal area. The labeling covers exclusively layer Ia. The lateral and medial entorhinal areas are also reached by fibers from the prepiriform cortex. The projection to the medial entorhinal area has not been described previously. Following injections of 3H-leucine into the PPCa transported labeling is present over the entire expanse of the entorhinal cortex and is located over layer Ib with the greatest density in its superficial part. Injections of 3H-leucine into the PPCp give rise to transported labeling over much of the entorhinal cortex. No labeling was found over the most medial parts of the medial subdivision (VMEA) of the lateral entorhinal area and the medial entorhinal area. Labeling occupies layer Ib, especially its middle part, and layers II and III. Both PPCa and PPCp appear to project most heavily to the dorsal (DLEA) and ventral (VLEA) subdivisions of the lateral entorhinal area. From the retrograde experiments it can be inferred that cells of layers II and III of the PPCa project predominantly to the DLEA, whereas those of the PPCp project predominantly to the VLEA. The MEA receives its heaviest projection from layer II of both PPCa and PPCp. In control experiments with 3H-leucine injections into the endopiriform nucleus it was found that this nucleus projects to the entire expanse of the entorhinal cortex. The fibers distribute to all layers with the exception of layer Ia.Abbreviations AI
agranular insular cortex
- AL
lateral nucleus of the amygdala
- BL
basolateral nucleus of the amygdala
- BM
basomedial nucleus of the amygdala
- C
claustrum
- CoA
cortical nucleus of the amygdala
- DLEA
dorsal division of the lateral entorhinal cortex
- END
endopiriform nucleus
- H
hippocampus
- I
granular insular cortex
- lot
lateral olfactory tractus
- MCL
mitral cell layer of the olfactory bulb
- MEA
medial entorhinal area
- OB
olfactory bulb
- PPCa
anterior part of the prepiriform nucleus
- PPCp
posterior part of the prepiriform nucleus
- VLEA
ventral division of the lateral entorhinal cortex
- VMEA
ventromedial division of the lateral entorhinal cortex
- 35
area 35 of the perirhinal cortex
- 36
area 36 of the perirhinal cortex |
| |
Keywords: | Olfactory pathways Prepiriform cortex Entorhinal cortex Laminar fiber distribution Axonal transport |
本文献已被 PubMed SpringerLink 等数据库收录! |
|