慢性病防治工作开启新篇章: 读《中国防治慢性病中长期规划(2017—2025年)》有感

目的了解温泉泡浴对人群抗氧化功能的影响。方法以贵州3种典型温泉(偏硅酸型、温矿泉型和温度型)地区为调查点，根据纳入、排除标准，结合问卷及体检结果，确定421名当地居民为泡浴观察对象。最终311名观察对象完成了持续4周、每周5 d、每天1次的40~50 min的规范化温泉泡浴，并进行了干预前后的健康体检。采集观察对象2次体检清晨空腹静脉血并分离血清，采用酶学法检测血清中氧化应激相关指标总超氧化物歧化酶(T-SOD)、铜-锌超氧化物歧化酶(Cu-Zn SOD)、谷胱甘肽硫转移酶(GSTs)、谷胱甘肽过氧化物酶(GSH-Px)、巯基(-SH)和丙二醛(MDA)的水平。结果整体性比较显示，与泡浴前相比，泡浴干预后观察对象血清中抗氧化酶T-SOD、Cu-Zn SOD、GSTs和GSH-Px活力明显升高(均P < 0.05)，抗氧化物质-SH含量有上升趋势，但差异无统计学意义(P > 0.05)，脂质过氧化产物MDA明显下降(P < 0.05)。分类型比较显示，不同类型温泉对抗氧化酶的影响存在差异，偏硅酸型温泉泡浴后观察对象血清中GSTs和GSH-Px的活性明显升高(均P < 0.05)，温矿泉型温泉泡浴后观察对象血清中T-SOD和Cu-Zn SOD的活性明显升高(均P < 0.05)，温度型温泉泡浴后观察对象血清中T-SOD、Cu-Zn SOD和GSTs的活性明显升高(均P < 0.05);3种类型温泉泡浴后观察对象血清中-SH水平均有上升趋势，但差异无统计学意义(均P > 0.05);3种类型温泉泡浴后观察对象血清中MDA水平均明显下降(均P < 0.05)。结论总体上温泉泡浴后人群血清中抗氧化酶活性升高，脂质过氧化水平降低; 不同温泉类型其氧化应激相关指标结果略有不同，偏硅酸型温泉泡浴后人群主要显示谷胱甘肽酶(GSTs和GSH-Px)活性升高，温矿泉型和温度型温泉泡浴后人群主要显示超氧化物歧化酶(SOD)活性升高，3种典型温泉泡浴后人群均显示机体脂质过氧化水平降低，提示温泉泡浴对提升机体的抗氧化功能可能有一定作用。

Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence

ObjectiveTo understand the influence of hot spring bathing intervention on population's antioxidation functions.MethodsThree typical types of hot spring(metasilicic acid type, warm mineral type and temperature type)in Guizhou Province were selected for investigation. According to the inclusion-exclusion criteria, questionnaires and physical examinations results, 421 individuals were selected as observation subjects for hot spring bathing intervention, of which 311 subjects completed 40 to 50 minutes of intervention once a day, 5 days a week, and for 4 weeks. Two physical examinations before and after the intervention were conducted for the 311 subjects. The fasting venous blood samples on the mornings of two physical examinations were collected and the serum was separated. Levels of serum oxidative stress-related parameters including total superoxide dismutase(T-SOD), copper zinc superoxide dismutase(Cu-Zn SOD), glutathione sulfur transferases(GSTs)glutathione peroxidase(GSH-px), sulfhydryl(-SH)and malondialdehyde(MDA)were measured by enzymatical methods.ResultsThe overall comparison showed that compared with before the bathing intervention, the levels of antioxidant enzymes including T-SOD, Cu-Zn SOD, GSTs and GSH-px significantly increased in serum after the intervention(all P < 0.05). There was an increasing trend of serum -SH level after the intervention, but with no statistical differences were seen(P > 0.05). MDA, a product of lipid peroxidation, significantly decreased in serum after the intervention(P < 0.05). The results of classified comparison showed that the effects of different hot spring types on antioxidant enzymes were different. Metasilicic acid type significantly increased the activities of GSTs and GSH-px in serum(all P < 0.05), warm mineral type significantly increased the activities of T-SOD and Cu-Zn SOD in serum(all P < 0.05), and temperature type significantly increased the activities of T-SOD, Cu-Zn SOD and GSTs in serum(all P < 0.05). There were increasing trends of serum -SH levels after bathing intervention of all three hot spring types, but no statistical differences were seen(all P > 0.05). The serum MDA levels decreased significantly after bathing intervention of all three types of hot springs(all P < 0.05).ConclusionOverall, bathing intervention of hot springs can improve the activities of antioxidant enzymes and reduce lipid peroxidation products in population. The results of oxidative stress parameters are slightly different in different types of hot springs. The subjects mainly show the elevation of glutathione related enzyme(GSTs and GSH-px)activities after intervention of metasilicic acid type, the elevation of superoxide dismutase(SOD)activities after intervention of warm mineral type and temperature type, and the decline of lipid peroxidation levels after intervention of all three types. It suggests that hot spring bathing may have certain effects on improving the body's antioxidation functions.