Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers |
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| Authors: | Hajime Nakamura Kohichi Takada Makoto Emori Naotaka Hayasaka Shintaro Sugita |
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| Affiliation: | 1.Department of Medical Oncology, Sapporo Medical University School of Medicine, Japan; 2.Department of Orthopedics, Sapporo Medical University School of Medicine, Japan; 3.Department of Surgical Pathology, Sapporo Medical University School of Medicine, Japan |
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| Abstract: | We herein report a rare case of unresectable liposarcoma that showed a complete response to eribulin. Furthermore, a low expression of phosphorylated AKT (p-AKT) on an immunohistological evaluation was observed. This result is consistent with our previous preclinical study that demonstrated the significance of p-AKT signaling for eribulin resistance in multiple subtypes of soft tissue sarcoma (STS) cells. This case highlights the potential benefits of eribulin as well as the mechanism underlying resistance to eribulin in patients with unresectable or metastatic STS, especially liposarcoma. |
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| Keywords: | eribulin liposarcoma phosphorylated AKT |
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