t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia |
| |
| Authors: | Vizmanos José L Larráyoz María J Lahortiga Idoya Floristán Filomena Alvarez Carmen Odero María D Novo Francisco J Calasanz María J |
| |
| Institution: | Department of Genetics, School of Science, University of Navarra, C/Irunlarrea s/n, 31080 Pamplona, Spain. jlvismanos@unav.es |
| |
| Abstract: | Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
