Links Between Maternal Cardiovascular Disease and the Health of Offspring |
| |
| Institution: | 1. Westmead Institute for Maternal and Fetal Medicine, Westmead Hospital, Westmead, New South Wales, Australia;2. Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia;3. Westmead Applied Research Centre, University of Sydney, Westmead, New South Wales, Australia;4. Department of Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland;5. Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada;6. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada;7. Population Health Research Institute, Hamilton, Ontario, Canada;8. McMaster University, Department of Medicine, Hamilton, Canada;9. Division of Maternal-Fetal Medicine, Departments of Obstetrics & Gynecology, Radiology, and Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada;1. Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;2. Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;3. Division of Cardiology, Department of Pediatrics, Doernbecher Children''s Hospital, Oregon Health and Science University, Portland, Oregon, USA |
| |
| Abstract: | Maternal cardiovascular disease (CVD) during pregnancy is on the rise worldwide, as both more women with congenital heart disease are reaching childbearing age, and conditions such as diabetes, hypertension, and obesity are becoming more prevalent. However, the extent to which maternal CVD influences offspring health, as a neonate and later in childhood and adolescence, remains to be fully understood. The thrifty phenotype hypothesis, by which a fetus adapts to maternal and placental changes to survive a nutrient-starved environment, may provide an answer to the mechanism of maternal CVD and its impact on the offspring. In this narrative review, we aim to provide a review of the literature pertaining to the impact of maternal cardiovascular and hypertensive disease on the health of neonates, children, and adolescents. This review demonstrates that maternal CVD leads to higher rates of complications among neonates. Ultimately, our review supports the hypothesis that maternal CVD leads to intrauterine growth restriction (IUGR), which, through the thrifty phenotype hypothesis and vascular remodelling, can have health repercussions, including an impact on CVD risk, both in the immediate newborn period as well as later throughout the life of the offspring. Further research remains crucial in elucidating the mechanism of maternal CVD long-term effects on offspring, as further understanding could lead to preventive measures to optimise offspring health, including modifiable lifestyle changes. Potential treatments for this at-risk offspring group could mitigate risk, but further studies to provide evidence are needed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
