Impact of muscle volume loss on acute oral mucositis in patients undergoing concurrent chemoradiotherapy after oral cancer resection |
| |
| Affiliation: | 1. Department of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan;2. Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan;3. Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan;1. Araçatuba School of Dentistry – UNESP, São Paulo, Brazil;2. Bauru School of Dentistry, University of São Paulo – USP, São Paulo, Brazil;3. Department of Diagnosis and Surgery, Araçatuba School of Dentistry – UNESP, São Paulo, Brazil;1. Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, PR China;2. Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, PR China;3. Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Centre, Nanjing Medical University, Nanjing, PR China;1. Department of Oral and Maxillofacial Surgery, Maharana Pratap Dental College, Kanpur, UP, India;2. Department of Periodontology, Maharana Pratap Dental College, Kanpur, UP, India;1. Division of Oral and Maxillofacial Surgery, Department of Disease Management Dentistry, Tohoku University Graduate School of Dentistry, Japan;2. Division of Oral Diagnosis, Department of Disease Management Dentistry, Tohoku University Graduate School of Dentistry, Japan;3. Department of Diagnostic Radiology, School of Medicine, Tohoku University, 1-1 Seiryo-cho Aoba-ku, Sendai, Japan;4. Division of Oral Pathology, Department of Disease Management Dentistry, Tohoku University Graduate School of Dentistry, Japan |
| |
| Abstract: | This study evaluated the association between skeletal muscle mass depletion and severe oral mucositis in patients undergoing concurrent chemoradiotherapy after oral cancer resection. Skeletal muscle mass was evaluated in 60 patients using the skeletal muscle index, which was based on skeletal muscle cross-sectional area (on computed tomography) at the level of the third lumbar vertebra. In accordance with the grading criteria of the Radiation Therapy Oncology Group, patients with a grade ≥3 were defined as having severe oral mucositis. Multivariate logistic regression analysis was used to evaluate independent risk factors for severe oral mucositis. Eleven patients (18.3%) were diagnosed with low skeletal muscle mass. Severe oral mucositis occurred in 17 (28.3%) patients, and the mean skeletal muscle index was 42.8 cm2/m2. A low skeletal muscle mass (hazard ratio 18.1; P = 0.001) and a chemotherapy regimen consisting of 5-fluorouracil and cisplatin (versus cisplatin only) (hazard ratio 5.5; P = 0.015) were independent risk factors for severe oral mucositis. Future prospective studies are warranted to identify effective pre- and perioperative exercises and nutrition programmes to increase low skeletal muscle mass and reduce the incidence of severe oral mucositis in patients undergoing concurrent chemoradiotherapy after oral cancer resection. |
| |
| Keywords: | sarcopenia oral mucositis head and neck cancer skeletal muscle radiation chemotherapy |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
