孕妇细菌性阴道病阴道乳酸杆菌的变化及意义

目的 观察正常孕妇、细菌性阴道病孕妇阴道乳酸杆菌的变化，并探讨其意义。为临床开展细菌性阴道病的微生态治疗提供理论依据。方法 选择妊娠妇女309名，其中患细菌性阴道病孕妇50名。采用生物化学的方法对孕妇阴道内乳酸杆菌进行鉴定，观察孕妇阴道内乳酸杆菌的分布情况，比较孕妇阴道内4种常见乳酸杆菌产生过氧化氢、降低培养环境pH的能力。结果 正常孕妇阴道内乳酸杆菌的检出率明显高于细菌性阴道病。孕期阴道内的优势乳酸杆菌是卷曲乳酸杆菌和嗜酸乳酸杆菌，其大多数可产生H2O2，降低培养环境PH能力较强。结论 H2O2阳性的乳酸杆菌在防御孕妇阴道感染中起重要作用。

Significance of the changes of vaginal lactobacilli in bacterial vaginosis in pregnant women

Objective To explore the significance of the changes of vaginal lactobacilli in normal pregnant women and those with bacterial vaginosis(BV). Methods A total of 309 pregnant women, including 50 pregnant women with bacterial vaginosis, were randomly selected. Lactobacilli isolated from the vaginas of pregnant women were identified by biochemical methods. The distribution of lactobacilli in the vaginas of pregnant women was observed. The ability to produce H 2O 2 and decrease the culture environment PH among four common lactobacilli in the vaginas of pregnant women was also compared. Results The detectable rate of lactobacilli in vaginas of the normal pregnant women was obviously higher than that of women with bacterial vaginosis. The predominant lactobacilli colonizing in the vaginas of the normal pregnant women were L. crispatus and L. acidophilus , most of which could produce H 2O 2. The frequency of H 2O 2 positive isolation in the vaginas of pregnant women was significantly higher than that of BV. Conclusion The study indicates that H 2O 2 positive lactobacilli plays an important role in the protection against vaginal infections in pregnant women.