Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients |
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Authors: | Wada-Isoe K Wakutani Y Urakami K Nakashima K |
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Institution: | Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan. kewada@grape.med.tottori-u.ac.jp |
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Abstract: | OBJECTIVES: To investigate a possible implication of inflammatory processes in the development of dementia in cerebrovascular disease. PATIENTS AND METHODS: We examined the levels of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) (n = 26), ischemic cerebrovascular disease without dementia (CVD) (n = 11), vascular dementia (VD) (n = 11), and other neurological disorders (n = 21) using sensitive enzyme-linked immunosorbent assay. RESULTS: The CSF concentrations of IL-6 were significantly elevated in patients with VD compared with those of patients with AD or CVD. CONCLUSION: The CSF IL-6 levels are increased in patients with VD, suggesting that inflammatory mechanisms may be involved in the development of cognitive decline in some patients with cerebrovascular disease. CSF IL-6 may be a biological marker for dementia in cerebrovascular disease. |
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Keywords: | vascular dementia Alzheimer's disease cerebrovascular disease interleukin-6 cytokines tau protein cerebrospinal fluid biological marker |
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