早期宫颈癌术后中危因素定义及辅助治疗的研究进展

宫颈癌仍是中国常见的妇科肿瘤疾病。早期宫颈癌（FIGO分期ⅠB‐ⅡA期）的治疗常常首选根治性手术,术后病理往往存在不良预后因素影响患者的生存。根据NCCN指南推荐,存在中危因素（淋巴血管间隙受累、肿瘤大小或深层间质浸润）且符合Sedlis标准的宫颈癌患者,建议术后补充盆腔外照射±含顺铂同步化疗。但是目前早期宫颈癌术后中危因素的定义标准、辅助治疗的指征及方式仍存在争议,本文重点阐述早期宫颈癌根治术后中危因素的定义标准及辅助治疗的研究进展。

Research progress on the definition of intermediate risk factors and postoperative adjuvant therapy for early cervical cancer

Cervical cancer is still a common gynecolgical tumor in China. Radical surgery is often the first choice for the treatment of early stage cervical cancer (FIGO stage ⅠB‐ⅡA), and postoperative pathological examination often has adverse prognostic factors affecting the survival. According to the NCCN guidelines, patients with cervical cancer who meet Sedlis criteria and have intermediate‐risk factors (lymphatic vascular space involvement, tumor size or deep interstitial infiltration) are recommended to receive concurrent chemotherapy with postoperative pelvic external irradiation ± cisplatin. However, the diagnostic criteria, indications and methods of adjuvant therapy for patients with intermediate risk factors after early cervical cancer surgery are still controversial. In this article, research progress on the definition of intermediate risk factors for early cervical cancer after radical hysterectomy and adjuvant treatment was mainly reviewed.