上海市闵行区学龄女生青春期发育与甲状腺功能的相关性

目的 调查上海市闵行区学龄女生青春发育、碘营养及甲状腺功能状况,探讨青春发育对甲状腺功能的影响.方法 2019年1—3月采用整群抽样的方法,在上海市闵行区东、南、北和中片共选取6所初中,将新入学的532名预初女生纳入研究.对研究对象进行体格检查,收集尿样及血样以检测尿碘及甲状腺激素水平;采用青春发育事件自我评定量表(P...

Association between puberty development and thyroid function in school-aged girls in Minhang District,Shanghai

Objective To investigate the puberty development,iodine nutrition and thyroid function,and to explore their association among school-aged girls in Minhang District,Shanghai. Methods From Jan to Mar 2019,a cluster sampling method was used to select 6 junior high schools in the east,south,north,and middle areas in Minhang District,Shanghai.A total of 532 girls of Grade 6 in selected schools were included in the study.Physical examination was conducted,and their urine and blood samples were collected to determine urinary iodine concentration (UIC) and thyroid functions.Pubertal Development Scale (PDS) was used to define the pubertal stage.Multiple linear regression models and Logistic regression models were conducted to analyze the associations between puberty stage and thyroid functions. Results A total of 513 participants met the criteria and had complete data.Most of the participants were in pubertal stage 4,accounting for 47.17% (242/513),The urinary iodine on Thursday (median:172 μg/L) was significantly higher than that on Monday (median:134 μg/L)(P<0.01),and the weighed urinary iodine excretion was significantly different in girls with different pubertal stage (P=0.025).After adjusting for the iodine nutrition status,for each one point increase in PDS score,triiodothyronine (TT3),tetraiodothyronine (TT4) and free triiodothyronine (FT3) decreased by 0.47,0.01 and 0.10 nmol/L,respectively.For each one level increase in puberty stage,TT3,TT4 and FT3 decreased by 0.26,0.01 and 0.09 nmol/L,respectively.Girls in post-puberty had the lower levels of TT3 (OR=0.57,95%CI:0.34-0.95),TT4 (OR=0.54,95%CI:0.32-0.92) and FT3 (OR=0.53,95%CI:0.31-0.90) as compared with girls in pre-puberty. The levels of TT3 (OR=0.52,95%CI:0.35-0.77) and FT3 (OR=0.55,95%CI:0.37-0.81) were significantly lower in girls after menarche than those without menarche. Conclusion There is anassociation between pubertal stage and thyroid functions in school-aged girls during puberty in Minhang District,Shanghai.TT3,TT4,and FT3 levels decline with the process of puberty.