P16，P53及Ki67在子宫颈鳞状细胞癌（SCC），宫颈上皮内瘤变（CIN）及慢性炎症中表达水平及临床意义

The correlation between levator ANI injury and the top supported structure of pelvic oragan prolapse by pelvic floor ultrasound

Objective?To study the expression of P16, P53 and Ki67 in cervical squamous cell carcinoma (SCC), cervical intraepithelial neoplasia (CIN) and chronic cervicitis, and explore their correlation with clinical changes. Methods?People who received cervical cancer screening in the hospital from October 2019 to September 2021 were selected. According to the inclusion and exclusion criteria, 193 patients were finally enrolled, including 5 patients with cervical SCC, 92 patients with CIN (78 CIN1, 9 CIN2, 5 CIN3), 96 patients with chronic cervicitis. Cervical tissues were collected from different groups to detect the expression of P16, P53 and Ki67, and their correlation with cervical pathological changes was analyzed. Results?P16 positive rates in chronic cervicitis, CIN1~CIN3, and cervical SCC were 4.17%, 30.77%, 55.56%, 60.00%, and 80.00% respectively. P53 positive rates were 7.29%, 20.51%, 44.44%, 60.00%, and 60.00% respectively. Ki67 positive rates were 4.17%, 30.77%, 55.56%, 60.00%, and 80.00% respectively. P16 positive rates, P53 positive rates and Ki67 positive rates all showed an upward trend (P<0.05). The expression of P16 (r=0.462, P<0.05), P53 (r=0.353, P<0.05) and Ki67 (r=0.502, P<0.05) were positively correlated with cervical pathological changes. Conclusions?The expression levels of P16, P53 and Ki67 increase with the aggravation of cervical lesions. Therefore, detection of related indicators can help assess the condition of cervical lesions, which is beneficial to clinical prevention and treatment of cervical cancer.