2016—2021年全球结核研究现状及热点：基于VOSviewer的可视化分析

 目的 基于文献计量学方法对2016—2021年全球结核病研究现状及热点进行分析。方法 基于Web of Science核心合集数据库，检索索引日期为2016年1月1日至2021年11月18日的结核相关“article”及“review”。利用VOSviewer对发文特征、高被引论文、重点研究方向进行分析并进行主题词聚类，最终形成研究热点。结果 共检索到相关文献22 264篇，其中美国发文量最多（5 026篇，22.57%）、篇均被引频次12.55，中国大陆地区发文量排在第三位（3 116篇，14.00%）、篇均被引频次6.38。影响力最大的4个研究领域为：感染病学（infectious diseases）、微生物学（microbiology）、免疫学（immunology）、呼吸病学（respiratory system）。关键词主题聚类后得到的研究热点为：结核病疾病负担评估等流行病学研究、围绕潜伏结核感染治疗和结核疫苗研发的结核病预防、结核病快速分子诊断和免疫诊断技术、抗结核药物和耐药结核病治疗方案优化、结核感染免疫反应和致病机制等基础研究。结论 近六年结核病研究集中于疾病负担及各类新的诊断手段、治疗方法和预防措施，耐药结核病患者、儿童结核病患者、合并HIV感染者是研究重点关注人群。新冠期间需要保持对结核病的可持续性研究。

Global tuberculosis research status and hotspots from 2016 to 2021:visualization analysis based on VOSviewer

Objective To analyze the status and hotspots of global tuberculosis (TB) research from 2016 to 2021 based on bibliometric methods.Methods Based on the Web of Science Core Collection Database,we indexed "articles" and "reviews" related to TB from Jan 1,2016 to Nov 18,2021.Using VOSviewer to cluster the published features,highly cited papers,key research directions and subject headings,a summary of research hotspots was formed.Results A total of 22 264 articles were retrieved.The United States (5 026 papers,22.57%) published the most papers,with an average citation frequency of 12.55,and Chinese mainland ranked the third (3 116 papers,14.00%),with an average citation frequency of 6.38. The four most influential research areas were infectious diseases,microbiology,immunology,and respiratory system.The hotspots obtained after the clustering of keyword topics were epidemiological research including disease burden assessment,TB prevention regarding to latent TB infection treatment and TB vaccine development,TB rapid molecular diagnosis and immunology diagnosis technology,anti-TB drugs and treatment for drug resistant TB,TB infection immune response and pathogenic mechanism.Conclusion In the past six years,TB research focused on disease burden and various new diagnostic methods,treatment methods, and preventive measures.Drug-resistant tuberculosis patients,childhood tuberculosis patients,and HIV-infected patients were the key populations for research. TB research needs to be sustainable during COVID-19 pandemic.