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基于不同感受野的鼻咽癌靶区和危及器官自动分割网络研究
引用本文:刘裕良,李永宝,亓孟科,吴艾茜,陆星宇,宋婷,周凌宏. 基于不同感受野的鼻咽癌靶区和危及器官自动分割网络研究[J]. 中华放射肿瘤学杂志, 2021, 30(5): 468-474. DOI: 10.3760/cma.j.cn113030-20200901-00447
作者姓名:刘裕良  李永宝  亓孟科  吴艾茜  陆星宇  宋婷  周凌宏
作者单位:南方医科大学生物医学工程学院,广州 510515; 中山大学肿瘤防治中心放疗科,广州 510060
基金项目:国家自然科学基金(81571771);广东省自然科学基金(2018A0303100020)
摘    要:目的:研究基于不同感受野的鼻咽癌靶区和危及器官自动分割网络。方法:收集100例鼻咽癌患者放疗数据,包含患者CT图像和医生勾画的靶区(GTV)和危及器官。随机选取90例数据作为训练集,另10例作为验证集。首先对图像进行中心裁剪、随机垂直翻转和旋转(-30°~30°)数据增强方式,输入至本文提出的MA_net网络进行训练,...

关 键 词:不同感受野  鼻咽肿瘤/放射疗法  自动分割网络
收稿时间:2020-09-01

Different receptive fields-based automatic segmentation network for gross target volume and organs at risk of patients with nasopharyngeal carcinoma
Liu Yuliang,Li Yongbao,Qi Mengke,Wu Aiqian,Lu Xingyu,Song Ting,Zhou Linghong. Different receptive fields-based automatic segmentation network for gross target volume and organs at risk of patients with nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2021, 30(5): 468-474. DOI: 10.3760/cma.j.cn113030-20200901-00447
Authors:Liu Yuliang  Li Yongbao  Qi Mengke  Wu Aiqian  Lu Xingyu  Song Ting  Zhou Linghong
Affiliation:School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
Abstract:Objective To establish an automatic segmentation network based on different receptive fields for gross target volume (GTV) and organs at risk in patients with nasopharyngeal carcinoma. Methods Radiotherapy data of 100 cases of nasopharyngeal carcinoma including CT images and GTV and organs at risk delineated by the physicians were collected. Ninety plans were randomly selected as the training dataset, and the other 10 plans as the validation dataset. Firstly, the images were subject to three data augmentation methods including center cropping, vertical flipping and rotation (-30°to 30°), and then input into MA_net networks proposed in this study for training. The model performance of networks was assessed by the number of network parameters (NP), floating-point number (FPN), the running memory (RM) and Dice index (DI), and eventually compared with DeeplabV3+, PSP_net, UNet++ and U_Net networks. Results When the input image was in the size of 240×240, MA_net had a NP of 23.20%, 20.10%, 25.55% and 27.11% of these 4 networks, 50.02%, 19.86%, 6.37% and 13.44% for the FPN, 40.63%, 23.60%, 11.58% and 14.99% for the RM, respectively. For the DI of GTV, MA_net was 1.16%, 2.28%, 1.27% and 3.59% higher than these 4 networks. For the average DI of GTV and OAR, MA_net was 0.16%, 1.37%, 0.30% and 0.97% higher than these 4 networks. Conclusion Compared with those four networks, the proposed MA_net network has slightly higher Dice index with fewer parameters, lower FPN and smaller RM.
Keywords:Different receptive fields  Nasopharyngeal neoplasm/radiotherapy  Automatic segmentation network  
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