两种促排卵方案用于卵巢储备功能下降患者的自身对照研究#br#

A self-control study of two ovarian stimulation protocols in patients with diminished ovarian reserve

Objective?To analyze self-control study of the progestin-primed ovarian stimulation(PPOS) and antagonist protocol in the patients with diminished ovarian reserve (DOR). Methods?A retrospective analysis was performed on 56 DOR patients receiving IVF/ICSI-ET in our hospital from January 2017 to July 2020. All patients were treated with antagonist protocol and PPOS protocol, the ovulation induction and pregnancy outcome were compared between the two ovulation induction schemes. Results?There were no statistical difference in the basic situation of Gn on launch day, AFC, the duration and total doses of gonadotropin, E2 levels and number of follicles≥14 mm on trigger day, number of retrieved oocytes, MⅡ oocytes, 2PN embryos, normal fertilization rate, high quality embryo rate, cycle cancellation rate, implantation rate, biochemical pregnancy rate and clinical pregnancy rate among the two groups (P＞0.05). The LH levels on trigger day [(6.11±6.33) U/L vs. (3.05±2.59) U/L], premature LH surge rate (17.86% vs. 1.79%), cycle cancellation rate (41.07% vs. 26.79%) in the antagonist group were significantly higher than those in the PPOS group (P＜0.05), while the available embryos rate (66.67% vs. 86.06%) was lower than PPOS group. Conclusions?The ovulation induction and pregnancy outcome of the two protocols were comparable for patients with DOR, while PPOS protocols can more effectively control the occurrence of premature LH surge, improve the embryo utilization rate, reduce cycle cancellation rate.