CSF 5-HIAA, suicide intent and hopelessness in the prediction of early suicide in male high-risk suicide attempters |
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Authors: | Samuelsson M Jokinen J Nordström A-L Nordström P |
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Affiliation: | Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Center, Karolinska University Hospital, Stockholm, Sweden. |
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Abstract: | OBJECTIVE: To study the predictive value of the Beck Suicide Intent Scale (SIS), the Beck Hopelessness Scale (BHS) and of 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid for future early suicide in a group of high-risk male suicide attempters. METHOD: Fifteen consecutive male suicide attempters admitted to a psychiatric ward at the Karolinska Hospital, who were not receiving any treatment with antidepressants were diagnosed according to DSM-III, assessed with SIS and BHS and submitted to lumbar puncture. All patients were followed up for cause of death. RESULTS: Five early suicides (within 2 years) were identified. Mean cerebrospinal fluid (CSF) 5-HIAA differed between suicides and survivors. Low CSF 5-HIAA was identified in those who committed early suicide. Neither the Suicide Intent Score nor the Hopelessness Score distinguished suicides from survivors. CONCLUSION: In high suicide risk hospitalized male psychiatric patients CSF 5-HIAA may be a better predictor of early suicide after attempted suicide than SIS or BHS. |
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Keywords: | suicide suicide attempt CSF 5‐HIAA serotonin hopelessness suicide intent |
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