Effect of age and carbon tetrachloride on cytokine concentrations in rat liver. |
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| Authors: | L E Rikans L A DeCicco K R Hornbrook T Yamano |
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| Institution: | University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. |
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| Abstract: | Interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in livers of young-adult and old rats administered carbon tetrachloride or vehicle. IL-1beta levels were higher and IL-6 levels were lower in old rats than in young-adult rats. Carbon tetrachloride treatment increased IL-1beta and decreased TNF-alpha and IL-6. The elevation in IL-1beta was diminished by aging. These results indicate that the increase in carbon tetrachloride hepatotoxicity that occurs in old age could be related to a dysregulation of inflammatory cytokines. |
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