| 大黄素抑制血管平滑肌细胞增殖的研究进展 |
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| 引用本文： | 卢聪,陈玉成,曾智. 大黄素抑制血管平滑肌细胞增殖的研究进展[J]. 中国中药杂志, 2012, 37(4): 417-420 |
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| 作者姓名： | 卢聪 陈玉成 曾智 |
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| 作者单位： | 四川大学华西医院心内科,四川成都,610041 |
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| 摘 要： | 大黄素(emodin)具有抗炎、抗肿瘤、免疫调节等多种药理作用,同时大黄素也能抑制血管平滑肌细胞的增殖。国内外的多项研究都已证实大黄素能明显抑制血管平滑肌细胞的增殖,抑制细胞的迁移,促进细胞凋亡,并从多个方面对其进行了相关机制的探讨。同时,结合临床的转化性研究和应用探索也已展开。现就大黄素抑制血管平滑肌细胞增殖的研究进展做一综述。
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| 关 键 词： | 大黄素 血管平滑肌细胞 |
| 收稿时间： | 2010-12-03 |
Research progress of the anti-proliferation effect of emodin on VSMCs |
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| LU Cong,CHEN Yucheng and ZENG Zhi. Research progress of the anti-proliferation effect of emodin on VSMCs[J]. China Journal of Chinese Materia Medica, 2012, 37(4): 417-420 |
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| Authors: | LU Cong CHEN Yucheng ZENG Zhi |
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| Affiliation: | Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China;Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China;Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China |
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| Abstract: | Emodin has such pharmacological effects as ant-inflammatory, anti-tumor, immunoregulation. Meanwhile, emodin could be used for inhibiting the proliferation of vascular smooth muscle cells (VSMC). Many foreign studies demonstrated that emodin had an effect on inhibiting proliferation of VSMCs and cell migration and promoting cell apoptosis, and probed into molecular mechanisms in all aspects. Besides, clinical translational researches and application explorations were also carried out. This article summarizes the research progress of the anti-proliferation effect of emodin on VSMCs. |
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| Keywords: | emodin vascular smooth muscle cell |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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