| 黄芩素对帕金森病的神经保护作用 |
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| 引用本文： | 于昕,何国荣,杜冠华.黄芩素对帕金森病的神经保护作用[J].中国中药杂志,2012,37(4):421-425. |
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| 作者姓名： | 于昕 何国荣 杜冠华 |
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| 作者单位： | 1. 烟台大学药学院,山东烟台,264005
2. 中国医学科学院北京协和医学院药物研究所“药物靶点研究与新药筛选”北京市重点实验室,北京,100050 |
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| 摘 要： | 黄芩素是从传统中药黄芩的干燥根中提取的黄酮类化合物,具有抗炎和抗氧化作用。随着其作用机制的不断研究,近些年发现黄芩素在帕金森病等神经系统退行性疾病的临床症状改善和神经保护方面也有一定的效果。目前研究发现其神经保护机制与抗炎,抑制氧化应激,保护线粒体,拮抗谷氨酸神经毒性,神经生长因子样作用以及抑制α-synuclein聚集等密切相关。该文从黄芩素对帕金森病的神经保护方面进行综述。
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| 关 键 词： | 黄芩素 帕金森病 神经保护作用 |
| 收稿时间： | 2011/2/15 0:00:00 |
Neuroprotective effect of baicalein in patients with Parkinson's disease |
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| YU Xin,HE Guorong and DU Guanhua.Neuroprotective effect of baicalein in patients with Parkinson's disease[J].China Journal of Chinese Materia Medica,2012,37(4):421-425. |
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| Authors: | YU Xin HE Guorong and DU Guanhua |
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| Institution: | Department of Pharmacology, School of Pharmacy, Yantai University, Yantai 264005, China;Beijing Key laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Beijing Key laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Baicalein, a flavonoid compound extracted from dried roots of traditional Chinese medicine Scutellaria baicalensis, has been widely applied as an antioxidant and anti-inflammatory agent. With continuous studies on its mechanisms, recent findings suggest that baicalein has some effect on neuroprotection and improvement of clinical symptoms in neurodegenerative diseases such as Parkinson's disease. Recent studies showed that its neuroprotective efficacy is closely related to such functions as antiinflammatory, antioxidative stress, protecting chondriosome, inhibiting glutamate neurotoxicity, promoting nerve growth and inhibiting alpha-synuclein protein-aggregate activities. The aim of this article is to summarize the neuroprotective effects of baicalein in Parkinson's disease. |
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| Keywords: | baicalein Parkinson's disease neuroprotective effect |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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