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Effect of Lactose, Dextran and Albumin on Recovery and Survival of Frozen Red Cells |
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| Authors: | Max M. Strumia Paul V. Strumia M. Elizabeth Burns M.S. Ann Dugan B.S. Burr Alter B.A. Richard Benner |
| Affiliation: | John S. Sharpe Research Foundation and the Laboratory of Clinical Pathology of The Bryn Mawr Hospital, Bryn Mawr, Pennsylvania |
| Abstract: | We have studied the effect of albumin and dextran, with and without previous modification with lactose, on the recovery and posttransfusion survival of red cells subjected to rapid freezing and thawing. Dextran and albumin have been found to protect red cells during freezing and thawing, with a recovery rate of 98.5 and 98.57%, respectively. A mean survival of 69.14% of red cells was obtained 24 hours posttransfusion when the red cells were treated with lactose, prior to freezing with dextran. A relationship has been found to exist between the mean corpuscular volume of the frozen red cells and the posttransfusion survival; potassium loss, stability, dimensional changes and O |
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