器官移植和免疫抑制剂药物使用的不良事件问卷调查

目的分析器官移植应用免疫抑制剂引起的各种不良事件，为临床安全用药提供参考。方法选择门诊定期随访的器官移植患者，药师参与器官移植门诊，指导患者填写CRF表，并负责整理、收集。结果共发出《免疫抑制剂药物不良事件流行病学调查表》200份，收回198份，回复率为99％。其中肝移植84例，肾移植114例。肝、肾移植患者中不良事件发生率较高的均为性功能下降（85．12％vs95．01％），感染（64．29％vs90．35％）。在肝移植中，感染发生率在不同性别间差异有统计学意义；体质指数、移植时间、并发疾病对血压有统计学意义；移植时间与血小板降低有显著相关（P〈0．05）。在肾移植中，性别和体质指数对体重增加有统计学意义；移植时间对高血压有统计学意义；年龄对高血糖有统计学意义；性别和移植时间对头痛有统计学意义；性别对多毛有统计学意义；体质指数及年龄分别对体型改变和脸部痤疮有高度统计学意义；年龄对视力障碍有统计学意义；移植时间对尿酸增高有统计学意义。结论器官移植后，不良事件发生率较高，临床药师如何辅助临床医师，加强对器官移植患者的用药管理，以降低不良事件的发生率，对进一步提高移植患者术后远期生存质量有着重要意义。

Retrospective investigation analysis of adverse drug event of immunodepressant in liver transplantation and renal transplantation patients

AIM To make the retrospective investigation analysis of adverse drug event （ADE） of immunodepressants in liver transplantation and renal transplantation patients and to provide the basis for rational and safe administration. METHODS The patients after liver or renal transplantation were selected and instructed to fill in the CRF（case report form） tables by pharmacists. The CRF tables were collected and analyzed by the pharmacists. RESULTS Two hundred CRF tables in all were sent out, 198 tables were retrieved.The recovery rate was 99%, in which liver transplantation CRF tables were 84 and renal transplantation CRF tables were 114. The higher incidence of ADE of immunodepressants was sexual function descent（85.12 % ）, infection（64.29 % ） in liver transplantation patients and sexual function descent（95.01 % ）, infection（90.35% ） in renal transplantation patients. It was shown that the infection was related to sexuality （ P 〈 0.05）. Blood pressure was related to weight index, blood type, time of transplantation and complication （ P 〈 0.05） ; platelet loss was related to time of transplantation （ P 〈 0.05） in liver transplantation. Meanwhile, frequency of hospitalization was related to blood type and complication （ P 〈 0.05） ; notalgia was related to blood type and time of transplantation （ P 〈 0.05） ; body weight increasing was related to of sexuality and weight index （ P 〈 0.05） ; blood pressure was related to time of transplantation （ P 〈 0.05） ; hyperglyeosemia was related to age （ P 〈 0.05） ; headache was related to sexuality and time of transplantation （ P 〈 0.05） ; hypertriehosis was related to sexuality （ P 〈 0.05） ; gingiva bleeding was related to blood type （ P 〈 0.05） ; change of body type and prosopo-aene were related to weight index and age （ P 〈 0.05） ; fatigue was related to blood type （ P 〈 0.05） ; visual disorder was related to age （ P 〈 0.05） ; raise up of uric acid was related to time of trans