米非司酮对围绝经期功血患者诱导闭经的效果

目的探讨米非司酮对围绝经期功血患者诱导闭经的效果。方法对无服药禁忌证、无手术适应证并自愿接受药物治疗的332例患者，行诊刮止血并排除恶性病变，连续服用米非司酮治疗6个月，观察诱导闭经效果，并检测血清生殖激素水平及子宫内膜厚度。结果服药期间所有患者均闭经，停药后301例患者直接进入绝经期，22例月经稀发，9例恢复正常月经；用药前后卵泡刺激素分别为（10．5±4．5）U·L^-1和（7．1±2．7）U·L^-1，黄体生成素分别为（8．1±1．7）U·L0和（5．8±2．5）U·L^-1，孕酮分别为（5．4±0．3）nmol·L^-1和（3．2±0．2）nmol·L^-1，雌二醇分别为（35．1±25．1）pmol·L^-1和（10．9±8．7）pmol·L^-1，催乳激素分别为（0．58±0．03）nmol·L^-1和（0．49±0．02）nmol·L^-1。子宫内膜明显萎缩；贫血得到纠正。结论使用米非司酮诱导围绝经期功血闭经效果显著，不良反应少。

Mifepristone induced amenorrhea of peri-menopausal period dysfunctional uterine bleeding

AIM To investigate the effect of mifepristone induced amenorrhea of peri-menopausal period dysfunctional uterine bleeding. METHODS Three hundred and thirty-two patients were selected without contraindication of using mfepristone and indication of operation. First we stopped bleeding by doing diagnostic curettages, precluded malignant disease, and then gave them low dose of mifepristone for 6 months to observe the effects of derivation of amenorrhea and the variations of endocrine and the thickness of endometrium. RESULTS In this period all patients were amenerrheic, after discontinuation 301 patients developed into critique age directly,22 patients became oligomenorrhea, and 9 patients reverted nomal flow. The sex hormone level＇s changing had statistical significantly between before and after treatment follicle-stimulatinghormone： （ 10.5 ± 4.5） U·L^-1 vs （7.1 ± 2.7） U·L^-1, luteinizing hormone： （ 8.1 ± 1.7）U·L^-1 vs （5.8 ± 2.5）U·L^-1, progesterone： （5.4 ± 0.3）nmol·L^-1 vs （3.2 ± 0.2）nmol·L^- 1,estradiol： （35.1 ± 25.1）pmol·L^-1 vs （ 10.9 ± 8.7） pmol·L^- 1, prolactin： （0.58 ± 0.03） nmol·L^-1 vs （0.49 ± 0.02） nmol·L^- 1]. The endometrium atrophied obviously and the anaemia was retrieved. CONCLUSION It has significant effect and little adverse reaction to use mifepristone to induce amenorrhea of period dysfunctional uterine bleeding.