维生素C微丸缓释胶囊的体外释放特征

目的建立维生素C微丸缓释胶囊体外释放度检测方法，评价其体外释放特性。方法以0．01mol·L^-1盐酸-0．03％乙二胺四乙酸二钠-0．05％L-半胱氨酸溶液为释放介质，介质体积为1000mL，转速为50r·min^-1，采用紫外-可见分光光度法于243nm波长处测定吸光度，转篮法评价体外释放特性。结果维生素C质量浓度在1．028～12．336mg·L^-1内与其吸收度之间呈良好线性关系（r=0．9999）；平均回收率为99．56％，RSD为0．86％。结论维生素C微丸缓释胶囊具有较好的释药性能和良好的缓释效果，符合《中国药典》要求。

In vitro release characteristics of capsules on vitamin C sustained release pellets

A/M To establish a method of in vitro release rate on sustained-release capsules of vitamin C pellets and characterize their release behavior. METHODS The medium was 0.01 mol· L^- 1 hydrochloride solution and 0.03 % disodium EDTA and 0.05% L- cysteine ;the volume was 1 000 mL; the rotation speed was 50 r·min^-1 and the absorba- bility was determined at 243 nm by ultraviolet-visible （UV） spectrophotometry. Rotate-basket method was employed to evaluate its in vitro release efficiency. RESULTS Vitamin C concentration in the 1. 028 - 12. 336 mg· L^- 1 showed a good linear relationship with its absorbability （ r = 0.999 9）. The average recovery was 99.56%, and RSD was 0.86%. CONCLUSION According to the Chinese pharmacopoeia standards, sustained-release capsules of vitamin C pellets have a better performance and a good sustained-release efficiency.