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Low platelet count in a 22q11 deletion syndrome subtype of schizophrenia |
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| Authors: | K Lazier E W C Chow P AbdelMalik L E Scutt R Weksberg A S Bassett |
| Institution: | a Schizophrenia Research Program, Queen Street Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, M6J 1H4 b Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada c Departments of Pediatrics and Genetics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada |
| Abstract: | Background: 22q11 Deletion Syndrome (22qDS) is a genetic syndrome associated with various physical features and schizophrenia. Some reports have identified thrombocytopenia (platelet count <150×109/l) in individuals with 22qDS, especially children. We investigated whether adults with 22qDS and schizophrenia (22qDS-SZ) have lower platelet counts than other patients with schizophrenia (SZ). Method: Complete blood counts (CBC) were recorded from medical records for 18 22qDS-SZ and 60 SZ subjects. Five CBCs per subject were randomly selected and used to calculate a within-subject mean for analyses. Results: 22qDS-SZ subjects had significantly lower mean platelet counts than comparison SZ subjects (142.2×109/l versus 282.5×109/l, t=−11.5, p<0.0001). Ten 22qDS-SZ (55%) and no comparison subjects had thrombocytopenia. Conclusions: These results suggest that thrombocytopenia may be a common feature of 22qDS and that low platelet counts may comprise a readily available screening criterion to help identify this genetic syndrome among adults with schizophrenia. |
| Keywords: | 22q Deletion syndrome Platelets Schizophrenia Thrombocytopenia Velocardiofacial syndrome |
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