磁共振弥散加权和动态增强成像评价晚期肝癌TACE术疗效研究进展

TACE是治疗晚期肝细胞癌较为成熟有效的方法,术后快速准确、创伤最小地评价其疗效,确定下一步治疗方案尤为重要.目前临床上评价TACE术后疗效主要取决于CT和MR形态成像,但事实上肿瘤功能特性改变早于形态变化.近年来,弥散加权成像(DWI)、多b值DWI、动态对比增强(DCE)成像等MR功能成像越来越多地用于定量评价肿瘤组织内水分子扩散和血流微循环灌注,且在评价肿瘤疗效上取得了一定进展.该文就上述功能成像方法研究进展及在TACE疗效评价中的应用现状作一综述.

Application of diffusion-weighted and dynamic contrast-enhanced MRI in evaluating the curative effect of TACE for advanced hepatocellular carcinoma: recent progress in research

Transcatheter arterial chemoembolization (TACE) has already been a mature and an effective treatment for advanced hepatocellular carcinoma (HCC).Clinically,it is very important to quickly and accurately evaluate the postoperative curative effect with minimally invasive technique so as to determine the next treatment options.At present,postoperative conventional CT and MRI are the main means to assess the curative effect of TACE,but it is a pity that after the treatment the functional changes of the tumor occur earlier than the morphological changes.In recent years,functional MRI techniques,such as diffusionweighted imaging (DWI),multi-b value DWI,dynamic contrast-enhanced (DCE) imaging,etc.have been more and more used for quantitative evaluation of the diffusion of water molecules and the blood microcirculation perfusion within the tumor tissue,and some progresses have been achieved in the evaluation of curative efficacy for tumor.This paper aims to make a comprehensive review about the research progress of the above mentioned functional imaging methods as well as their current application status in evaluation of the curative effect of TACE.